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384620 Sigma-AldrichHonokiol - CAS 35354-74-6 - Calbiochem

A biphenyl neolignan and an active principle of Magnolia extract that displays anti-angiogenic, anti-tumor and anxiolytic properties.

Honokiol - CAS 35354-74-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

分析证书
参考
Data Sheet

同义词: 5,3ʹ-Diallyl-2,4ʹ-dihydroxydiphenyl, VEGFR Tyrosine Kinase Inhibitor XIX, VEGFR2 Kinase Inhibitor XV

Primary Target: Anti-angiogenic, anti-tumor and anxiolytic properties

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
35354-74-6	C₁₈H₁₈O₂

价格及供货情况

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Description
Overview	A biphenyl neolignan and an active principle of Magnolia extract that displays anti-angiogenic, anti-tumor and anxiolytic properties. Shown to induce apoptosis and preferentially inhibit the growth of primary human endothelial cells over fibroblasts by blocking VEGFR2 autophosphorylation and subsequent rac activation. Also blocks the in vivo growth of SVR angiosarcoma in nude mice.
Catalogue Number	384620
Brand Family	Calbiochem®
Synonyms	5,3ʹ-Diallyl-2,4ʹ-dihydroxydiphenyl, VEGFR Tyrosine Kinase Inhibitor XIX, VEGFR2 Kinase Inhibitor XV

References
References	Bai, X., et al. 2003. J. Biol. Chem. 278, 35501. Yang, S.E., et al. 2002. Biochem. Pharmacol. 63, 1641. Son, H.J., et al. 2000. Planta Med. 66, 469. Maruyama, Y., et al. 1998. J. Nat. Prod. 61, 135.

Product Information
CAS number	35354-74-6
ATP Competitive	N
Form	White solid
Hill Formula	C₁₈H₁₈O₂
Chemical formula	C₁₈H₁₈O₂
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Anti-angiogenic, anti-tumor and anxiolytic properties
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
384620-10MGCN	04055977190267

Documentation

Honokiol - CAS 35354-74-6 - Calbiochem 分析证书

标题	批号
384620	输入批号

参考

参考信息概述
Bai, X., et al. 2003. J. Biol. Chem. 278, 35501. Yang, S.E., et al. 2002. Biochem. Pharmacol. 63, 1641. Son, H.J., et al. 2000. Planta Med. 66, 469. Maruyama, Y., et al. 1998. J. Nat. Prod. 61, 135.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	12-May-2008 RFH
Synonyms	5,3ʹ-Diallyl-2,4ʹ-dihydroxydiphenyl, VEGFR Tyrosine Kinase Inhibitor XIX, VEGFR2 Kinase Inhibitor XV
Description	The active principle of Magnolia extracts that exhibits anti-angiogenic, anti-tumor, anxiolytic, and chemoprotective properties. Shown to induce apoptosis and preferentially inhibit the growth of primary human endothelial cells over fibroblasts by blocking vascular endothelial growth factor receptor 2 (VEGFR2) autophosphorylation and subsequent rac activation. Also shown to block the growth of SVR angiosarcoma in nude mice.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	35354-74-6
Chemical formula	C₁₈H₁₈O₂
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (10 mg/ml) or Ethanol
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
Merck USA index	14, 4742
References	Bai, X., et al. 2003. J. Biol. Chem. 278, 35501. Yang, S.E., et al. 2002. Biochem. Pharmacol. 63, 1641. Son, H.J., et al. 2000. Planta Med. 66, 469. Maruyama, Y., et al. 1998. J. Nat. Prod. 61, 135.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Inducers > Apoptosis Inducers

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