Millipore Sigma Vibrant Logo

382175 Histone Deacetylase Inhibitor VIII - CAS 1045792-66-2 - Calbiochem

The Histone Deacetylase Inhibitor VIII, also referenced under CAS 1045792-66-2, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: HDAC Inhibitor VIII, N-(4-(3-(((7-Hydroxyamino-7-oxoheptyl)amino)carbonyl)-5-isoxazolyl)phenyl)-1,1-dimethylethylester, carbamic acid

View Products on Sigmaaldrich.com
382175
查看价格及供货情况

概述

Replacement Information

重要规格表

CAS #Empirical Formula
1045792-66-2C₂₂H₃₀N₄O₆

价格及供货情况

产品目录编号 库存情况包装 数量 / 包装 价格 数量
382175-1MGCN
正在查询供货情况......
—
目前缺货 目前缺货
有货 
停产
少量现货
供货情况有待确认
    其余：另行通知
      其余：另行通知
      另行通知
      联系客户服务
      Contact Customer Service

      		 1 mg
      正在检索价格......
      无法检索价格。
      最小订购数量为倍数
      Maximum Quantity is
      以订单确认为准 更多信息
      您节约了 ()。
       
      —
      Request Pricing
      		 —
      Description
      OverviewA cell-permeable, active site Zn2+-targeting phenylisoxazolo-hydroxamate that acts a potent and highly selective HDAC6 inhibitor (IC50 = 0.002, 0.42, 90.7, 252, 271 and 6851 nM against HDAC-6, -3, -10, -2, -1 and -8, respectively). Shown to be more potent than SAHA in inhibiting the proliferation of a panel of pancreatic cancer cell lines (IC50 <1.0 µM).
      Catalogue Number382175
      Brand Family Calbiochem®
      SynonymsHDAC Inhibitor VIII, N-(4-(3-(((7-Hydroxyamino-7-oxoheptyl)amino)carbonyl)-5-isoxazolyl)phenyl)-1,1-dimethylethylester, carbamic acid
      References
      ReferencesKozikowski, A.P., et al. 2008. J. Med. Chem. 51, 4370.
      Product Information
      CAS number1045792-66-2
      FormBeige to light brown solid
      Hill FormulaC₂₂H₃₀N₄O₆
      Chemical formulaC₂₂H₃₀N₄O₆
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      产品目录编号 GTIN
      382175-1MGCN 04055977212808

      Documentation

      Histone Deacetylase Inhibitor VIII - CAS 1045792-66-2 - Calbiochem MSDS

      职位

      物料安全数据表 (MSDS) 

      Histone Deacetylase Inhibitor VIII - CAS 1045792-66-2 - Calbiochem 分析证书

      标题批号
      382175

      参考

      参考信息概述
      Kozikowski, A.P., et al. 2008. J. Med. Chem. 51, 4370.
      数据表

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision29-November-2010 JSW
      SynonymsHDAC Inhibitor VIII, N-(4-(3-(((7-Hydroxyamino-7-oxoheptyl)amino)carbonyl)-5-isoxazolyl)phenyl)-1,1-dimethylethylester, carbamic acid
      DescriptionA cell-permeable, active site Zn2+-targeting phenylisoxazolo-hydroxamate that acts a potent and highly selective HDAC6 inhibitor (IC50 = 0.002, 0.42, 90.7, 252, 271 and 6851 nM against HDAC-6, -3, -10, -2, -1 and -8, respectively). Shown to be more potent than SAHA in inhibiting the proliferation of a panel of pancreatic cancer cell lines (IC50 <1.0 µM).
      FormBeige to light brown solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1045792-66-2
      Chemical formulaC₂₂H₃₀N₄O₆
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesKozikowski, A.P., et al. 2008. J. Med. Chem. 51, 4370.