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382149 Histone Deacetylase Inhibitor III

The Histone Deacetylase Inhibitor III, also referenced under CAS 251456-60-7, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications.

Histone Deacetylase Inhibitor III MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: M344, 4-Dimethylamino-N-(6-hydroxycarbamoylhexyl)benzamide, N-Hydroxy-7-(4-dimethylaminobenzoyl)aminoheptanamide

Primary Target: Rat liver HDAC
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382149
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
251456-60-7C₁₆H₂₅N₃O₃

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      		 塑胶安瓿;塑胶针药瓶 1 mg
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      Description
      OverviewA cell-permeable amide analog of Trichostatin A (Cat. No. 647925) that potently inhibits histone deacetylases (IC50 = 40 nM for rat liver HDAC and IC50 = 100 nM for maize HD). Induces differentiation and inhibits proliferation (~2 µM) of murine erythroleukemia cells.
      Catalogue Number382149
      Brand Family Calbiochem®
      SynonymsM344, 4-Dimethylamino-N-(6-hydroxycarbamoylhexyl)benzamide, N-Hydroxy-7-(4-dimethylaminobenzoyl)aminoheptanamide
      References
      ReferencesRamiszewski, S.W., et al. 2002. J. Med. Chem. 45, 753.
      Jung, M., et al. 1999. J. Med. Chem. 42, 4669.
      Product Information
      CAS number251456-60-7
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₆H₂₅N₃O₃
      Chemical formulaC₁₆H₂₅N₃O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetRat liver HDAC
      Primary Target IC<sub>50</sub>40 nM for rat liver HDAC
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      产品目录编号 GTIN
      382149-1MGCN 04055977213164

      Documentation

      Histone Deacetylase Inhibitor III MSDS

      职位

      物料安全数据表 (MSDS) 

      Histone Deacetylase Inhibitor III 分析证书

      标题批号
      382149

      参考

      参考信息概述
      Ramiszewski, S.W., et al. 2002. J. Med. Chem. 45, 753.
      Jung, M., et al. 1999. J. Med. Chem. 42, 4669.
      数据表

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-April-2011 RFH
      SynonymsM344, 4-Dimethylamino-N-(6-hydroxycarbamoylhexyl)benzamide, N-Hydroxy-7-(4-dimethylaminobenzoyl)aminoheptanamide
      DescriptionA cell-permeable, amide analog of Trichostatin A (Cat. No. 647925) that potently inhibits histone deacetylase (IC50 = 40 nM for rat liver HDAC and IC50 = 100 nM for maize HDAC). Induces differentiation and inhibits proliferation (~2 µM) of murine erythroleukemia cells.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number251456-60-7
      Chemical formulaC₁₆H₂₅N₃O₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (1 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesRamiszewski, S.W., et al. 2002. J. Med. Chem. 45, 753.
      Jung, M., et al. 1999. J. Med. Chem. 42, 4669.