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			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

382115 Sigma-AldrichHistone Acetyl Transferase Inhibitor VII, CTK7A - Calbiochem

The Histone Acetyl Transferase Inhibitor VII, CTK7A controls the biological activity of Histone Acetyl Transferase. This small molecule/inhibitor is primarily used for Cell Structure applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
技术信息
Data Sheet

同义词: Sodium-4-(3,5-bis(4-hydroxy-3-methoxystyryl)-1H-pyrazol-1-yl)benzoate, HBC, Na, HAT Inhibitor VII, p300/CBP Inhibitor V, PCAF Inhibitor III

Recommended Products

概述

Replacement Information

重要规格表

Empirical Formula
C₂₈H₂₃N₂NaO₆

价格及供货情况

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Description
Overview	A cell-permeable and water soluble hydrazinobenzoylcurcumin (HBC) compound that acts as a selective, reversible and mixed mode inhibitor of p300/CBP and PCAF histone acetyltransferases (IC₅₀ ≤ 25 and 50 µM, respectively) with minimal activity towards other histone modifying enzymes like, G9a, CARM1, HDAC1, SIRT2 and TIP60 (IC₅₀ > 100 µM). Blocks the autoacetylation of p300 and PCAF and histone acetylation, downregulates cyclin E expression and induces senescence-like growth arrest at 100 µM in KB cells. Further, suppresses tumor growth in xenograft oral tumor nude mouse model (100 mg/kg, i.p., b.i.d.) and reduces H3K14 and H3K9 acetylation levels. Reported to potently inhibit bFGF-induced bovine aortic endothelial cells (BAECs) invasion and tube formation with an IC₅₀ of 0.93 µM and binds to Ca²⁺/calmodulin with high-affinity (K_d = 8.11 µM) and antagonize its functions in HCT15 cells.
Catalogue Number	382115
Brand Family	Calbiochem®
Synonyms	Sodium-4-(3,5-bis(4-hydroxy-3-methoxystyryl)-1H-pyrazol-1-yl)benzoate, HBC, Na, HAT Inhibitor VII, p300/CBP Inhibitor V, PCAF Inhibitor III

References
References	Arif, M., et al. 2010. Chem. Biol. 17, 903. Shim, J.S., et al. 2004. Chem. Biol. 11, 1455. Shim, J.S., et al. 2002. Bioorg. Med. Chem. Biol. 10, 2439.

Product Information
Form	Tan powder
Hill Formula	C₂₈H₂₃N₂NaO₆
Chemical formula	C₂₈H₂₃N₂NaO₆
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥99% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
382115-10MGCN	04055977213126

Documentation

Histone Acetyl Transferase Inhibitor VII, CTK7A - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Histone Acetyl Transferase Inhibitor VII, CTK7A - Calbiochem 分析证书

标题	批号
382115	输入批号

参考

参考信息概述
Arif, M., et al. 2010. Chem. Biol. 17, 903. Shim, J.S., et al. 2004. Chem. Biol. 11, 1455. Shim, J.S., et al. 2002. Bioorg. Med. Chem. Biol. 10, 2439.

技术信息

标题
White Paper - The Message in the Marks: Deciphering Cancer Epigenetics

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	17-August-2012 JSW
Synonyms	Sodium-4-(3,5-bis(4-hydroxy-3-methoxystyryl)-1H-pyrazol-1-yl)benzoate, HBC, Na, HAT Inhibitor VII, p300/CBP Inhibitor V, PCAF Inhibitor III
Description	A cell-permeable and water soluble hydrazinobenzoylcurcumin (HBC) compound that acts as a selective, reversible and mixed mode inhibitor of p300/CBP and PCAF histone acetyltransferases (IC₅₀ ≤ 25 and 50 µM, respectively) with minimal activity towards other histone modifying enzymes like, G9a, CARM1, HDAC1, SIRT2 and TIP60 (IC₅₀ > 100 µM). Blocks the autoacetylation of p300 and PCAF and histone acetylation, downregulates cyclin E expression and induces senescence-like growth arrest at 100 µM in KB cells. Further, suppresses tumor growth in xenograft oral tumor nude mouse model (100 mg/kg, i.p., b.i.d.) and reduces H3K14 and H3K9 acetylation levels. Reported to potently inhibit bFGF-induced bovine aortic endothelial cells (BAECs) invasion and tube formation with an IC₅₀ of 0.93 µM and binds to Ca²⁺/calmodulin with high-affinity (K_d = 8.11 µM) and antagonize its functions in HCT15 cells.
Form	Tan powder
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₂₈H₂₃N₂NaO₆
Structure formula
Purity	≥99% by HPLC
Solubility	DMSO (100 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Arif, M., et al. 2010. Chem. Biol. 17, 903. Shim, J.S., et al. 2004. Chem. Biol. 11, 1455. Shim, J.S., et al. 2002. Bioorg. Med. Chem. Biol. 10, 2439.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > Histone Acetylase and Deacetylase Inhibitors

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