376816 Sigma-AldrichHexokinase II VDAC Binding Domain Peptide, Cell-Permeable - Calbiochem
A cell-permeable peptide analog of Hexokinase II VDAC binding domain peptide.
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同义词: HXK2VBD-cpm, H-RQIKIWFQNRRMKWKK-MIASHLLAYFFTELN-NH₂
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概述
重要规格表
| Empirical Formula |
|---|
| C₁₈₈H₂₉₁N₅₃O₄₀S₂ |
价格及供货情况
| 产品目录编号 | 库存情况 | 包装 | 数量 / 包装 | 价格 | 数量 | |
|---|---|---|---|---|---|---|
| 376816-1MGCN |
|
塑胶安瓿;塑胶针药瓶 | 1 mg |
|
— |
| Description | |
|---|---|
| Overview | A cell-permeable peptide analog of Hexokinase II VDAC binding domain peptide (Cat. No. 376815). The internalization domain of the Antennapedia homeoprotein is fused to the methionine amino terminal. Shown to completely detach and translocate HXK2 from mitochondria to the cytosol in HeLa cells at 100 µM. Does not induce Bax translocation or cytochrome c release when used alone. However, it markedly sensitizes cells to cytochrome c release and to the induction of apoptosis when used in combination with a Bax-dependent apoptosis inducer, Indomethacin (Cat. No. 405268). |
| Catalogue Number | 376816 |
| Brand Family | Calbiochem® |
| Synonyms | HXK2VBD-cpm, H-RQIKIWFQNRRMKWKK-MIASHLLAYFFTELN-NH₂ |
| References | |
|---|---|
| References | Pastorino, J.G., et al. 2002. J. Biol. Chem. 277, 7610. Holinger, E.P., et al. 1999. J. Biol. Chem. 274, 13298. Sui, D., and Wilson, J.E. 1997. Arch. Biochem. Biophys. 345, 111. |
| Product Information | |
|---|---|
| ATP Competitive | N |
| Form | White lyophilized solid |
| Formulation | Supplied as a trifluoroacetate salt. |
| Hill Formula | C₁₈₈H₂₉₁N₅₃O₄₀S₂ |
| Chemical formula | C₁₈₈H₂₉₁N₅₃O₄₀S₂ |
| Hygroscopic | Hygroscopic |
| Reversible | N |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | Detach and translocate HXK2 from mitochondria to the cytosol |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Peptide Sequence | H-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Met-Ile-Ala-Ser-His-Leu-Leu-Ala-Tyr-Phe-Phe-Thr-Glu-Leu-Asn-NH₂ |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| 产品目录编号 | GTIN |
| 376816-1MGCN | 04055977212976 |