Millipore Sigma Vibrant Logo

373270 Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1 - CAS 313553-47-8 - Calbiochem

概述

Replacement Information

重要规格表

CAS #Empirical Formula
313553-47-8C₁₈H₁₆N₂OS

价格及供货情况

产品目录编号 库存情况包装 数量 / 包装 价格 数量
373270-10MGCN
正在查询供货情况......
目前缺货
目前缺货
有货 
停产
少量现货
供货情况有待确认
    其余:另行通知
      其余:另行通知
      另行通知
      联系客户服务
      Contact Customer Service

      10 mg
      正在检索价格......
      无法检索价格。
      最小订购数量为倍数
      Maximum Quantity is
      以订单确认为准 更多信息
      您节约了 ()。
       
      Request Pricing
      Description
      OverviewA cell-permeable thiazolyl benzamide compound that directly binds Hec1 and disrupts Hec1/Nek2 complex formation, resulting in defective Hec1 kinetochores localization and cellular Nek2 destabilization/downregulation. Shown to induce a transient mitotic arrest in HeLa cultures and inhibit the proliferation of 10 breast cancer cell lines (GI50 of 10-21 µM) as well as the cervical HeLa and colon HCT116 cancer lines, while exhibiting reduced potency against the noncancerous MCF10A line (GI50 = 41 µM). Reported to suppress the MDA-MB-468-derived tumor growth (by ~53% and ~75% 3 wks after a 7-wk treatment period with 50 mg/kg and 100 mg/kg INH1, repectively, i.p.) in a murine breast cancer model in vivo.
      Catalogue Number373270
      Brand Family Calbiochem®
      SynonymsInhibitor of Nek2/Hec1-1, N-(4-(2,4-Dimethylphenyl)-thiazol-2-yl)-benzamide, INH1
      References
      ReferencesWu, G., et al. 2008. Cancer Res. 68, 8393.
      Product Information
      CAS number313553-47-8
      FormWhite solid
      Hill FormulaC₁₈H₁₆N₂OS
      Chemical formulaC₁₈H₁₆N₂OS
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      产品目录编号 GTIN
      373270-10MGCN 04055977191011

      Documentation

      Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1 - CAS 313553-47-8 - Calbiochem MSDS

      职位

      物料安全数据表 (MSDS) 

      Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1 - CAS 313553-47-8 - Calbiochem 分析证书

      标题批号
      373270

      参考

      参考信息概述
      Wu, G., et al. 2008. Cancer Res. 68, 8393.
      数据表

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-April-2011 RFH
      SynonymsInhibitor of Nek2/Hec1-1, N-(4-(2,4-Dimethylphenyl)-thiazol-2-yl)-benzamide, INH1
      DescriptionA cell-permeable thiazolyl benzamide compound that directly binds Hec1 and disrupts Hec1/Nek2 complex formation, resulting in defective Hec1 kinetochores localization and cellular Nek2 destabilization/downregulation. Shown to induce a transient mitotic arrest in HeLa cultures and inhibit the proliferation of 10 breast cancer cell lines (GI50 of 10-21 µM) as well as the cervical HeLa and colon HCT116 cancer lines, while exhibiting reduced potency against the noncancerous MCF10A line (GI50 = 41 µM). Reported to suppress the MDA-MB-468-derived tumor growth (by ~53% and ~75% 3 wks after a 7-wk treatment period with 50 mg/kg and 100 mg/kg INH1, repectively, i.p.) in a murine breast cancer model in vivo.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number313553-47-8
      Chemical formulaC₁₈H₁₆N₂OS
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (50 mg/ml) or Ethanol (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesWu, G., et al. 2008. Cancer Res. 68, 8393.