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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

385920 Sigma-AldrichHSP90 Inhibitor, CCT018159 - CAS 171009-07-7 - Calbiochem

The HSP90 Inhibitor, CCT018159, also referenced under CAS 171009-07-7, controls the biological activity of HSP90.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 4-(4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl)-6-ethylresorcinol

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
171009-07-7	C₂₀H₂₀N₂O₄

价格及供货情况

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Description
Overview	A cell-permeable pyrazoloresorcinol compound that inhibits HSP90 ATPase activity (IC₅₀ = 3.2 µM and 6.6 µM against human HSP90β and yeast HSP90, respectively) by targeting the enzyme's N-terminal ATP binding site. It exhibits no detectable effects against human Hsp70 or topoisomerase II even at concentrations as high as 100 µM and inhibits a panel of 20 commonly studied kinases only at much higher concentrations. Unlike 17-AAG (Cat. No. 100068), the antitumor activity of CCT018159 is not affected by the expression of NQ01/DT-diaphorase or P-glycoprotein.
Catalogue Number	385920
Brand Family	Calbiochem®
Synonyms	4-(4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl)-6-ethylresorcinol

References
References	Hardcastle, A., et al. 2007. Mol. Cancer Ther. 6, 1112. Sharp, S.Y., et al. 2007. Cancer Res. 67, 2206. Smith, N.F., et al. 2006. Mol. Cancer Ther. 5, 1628. Dymock, B.W., et al. 2005. J. Med. Chem. 48, 4212. Cheung, K.M., et al. 2005. Bioorg. Med. Chem. Lett. 15, 3338.

Product Information
CAS number	171009-07-7
Form	White solid
Hill Formula	C₂₀H₂₀N₂O₄
Chemical formula	C₂₀H₂₀N₂O₄
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥98% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/37/38 Irritating to eyes, respiratory system and skin.
S Phrase	S: 24/25-36/37/39 Avoid contact with skin and eyes. Wear suitable protective clothing, gloves and eye/face protection.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Irritant
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solution are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
385920-5MGCN	04055977189841

Documentation

HSP90 Inhibitor, CCT018159 - CAS 171009-07-7 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

HSP90 Inhibitor, CCT018159 - CAS 171009-07-7 - Calbiochem 分析证书

标题	批号
385920	输入批号

参考

参考信息概述
Hardcastle, A., et al. 2007. Mol. Cancer Ther. 6, 1112. Sharp, S.Y., et al. 2007. Cancer Res. 67, 2206. Smith, N.F., et al. 2006. Mol. Cancer Ther. 5, 1628. Dymock, B.W., et al. 2005. J. Med. Chem. 48, 4212. Cheung, K.M., et al. 2005. Bioorg. Med. Chem. Lett. 15, 3338.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	06-March-2008 JSW
Synonyms	4-(4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl)-6-ethylresorcinol
Description	A cell-permeable pyrazoloresorcinol compound that inhibits HSP90 ATPase activity (IC₅₀ = 3.2 µM and 6.6 µM against human HSP90β and yeast HSP90, respectively) by targeting the enzyme's N-terminal ATP binding site. It exhibits no detectable effects against human Hsp70 or topoisomerase II even at concentrations as high as 100 µM and inhibits a panel of 20 commonly studied kinases only at much higher concentrations. Unlike 17-AAG (Cat. No. 100068), the antitumor activity of CCT018159 is not affected by the expression of NQ01/DT-diaphorase or P-glycoprotein.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	171009-07-7
Chemical formula	C₂₀H₂₀N₂O₄
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (35 mg/ml), H₂O (1.7 mg/ml) or Ethanol (35 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solution are stable for up to 3 months at -20°C.
Toxicity	Irritant
References	Hardcastle, A., et al. 2007. Mol. Cancer Ther. 6, 1112. Sharp, S.Y., et al. 2007. Cancer Res. 67, 2206. Smith, N.F., et al. 2006. Mol. Cancer Ther. 5, 1628. Dymock, B.W., et al. 2005. J. Med. Chem. 48, 4212. Cheung, K.M., et al. 2005. Bioorg. Med. Chem. Lett. 15, 3338.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Heat Shock Protein Inhibitors

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