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400091 Sigma-AldrichHIF-Hydroxylase Inhibitor, DMOG - CAS 89464-63-1 - Calbiochem

HIF-Hydroxylase Inhibitor, DMOG, CAS 89464-63-1, is a cell-permeable 2-oxoglutarate (2-OG) analog that acts as a competitive inhibitor against all 2-OG-dependent dioxygenases.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: N-(Methoxyoxoacetyl)-glycine methyl ester, Dimethyloxalylglycine, HIF Prolyl Hydroxylase Inhibitor I, HIF Aspartyl β-Hydroxylase Inhibitor, HIF Asparanginyl β-Hydroxylase Inhibitor

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
89464-63-1	C₆H₉NO₅

价格及供货情况

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Description
Overview	A cell-permeable 2-OG (2-oxoglutarate) analog that is expected to act as a competitive inhibitor against all 2-OG-dependent dioxygenases. Effectively upregulates normoxia HIF-α transcription activity (effective conc. = 1 mM in cultures) by inhibiting HIF-PH- (HIF-α-prolyl hydroxylase) catalyzed ODD (oxygen-dependent degradation domain) Prolyl hydroxylation (Pro⁵⁶⁴ and Pro⁵³⁰ in HIF-1α and HIF-2α, respectively) and aspartyl/asparanginyl β-hydroxylase-catalyzed CAD Asp hydroxylation (Asn⁸⁰³ and Asn⁸⁵¹ in HIF-1α and HIF-2α, respectively), resulting in a blockage of pVHL (von Hippel-Lindau) ubiquitin ligase complex-mediated HIF-α degradation and a simultaneous promotion of HIF CAD (COOH-terminal activation domain) p300/CBP association. DMOG is also demonstrated to augment artery ligation-induced up-regulation of HIF-1α and FLK (by 100% and 40%, respectively, in 11 days; 8 mg/0.5 ml/animal/i.p.; q.o.d.) in muscle tissues in a murine ischaemic model in vivo.
Catalogue Number	400091
Brand Family	Calbiochem®
Synonyms	N-(Methoxyoxoacetyl)-glycine methyl ester, Dimethyloxalylglycine, HIF Prolyl Hydroxylase Inhibitor I, HIF Aspartyl β-Hydroxylase Inhibitor, HIF Asparanginyl β-Hydroxylase Inhibitor

References
References	Pollard, P.J., et al. 2008. Biochem. J. 416, 387. Chen, H., et al. 2006. Cancer Res. 66, 9009. Milkiewicz, M., et al. 2004. J. Physiol. 560, 21. Lando, D., et al. 2002. Science 295, 858. Jaakkola, P., et al. 2001. Science 292, 468.

Product Information
CAS number	89464-63-1
Form	Pink-white to peach-white
Hill Formula	C₆H₉NO₅
Chemical formula	C₆H₉NO₅
Hygroscopic	Hygroscopic
Structure formula Image
Quality Level	MQ100

Applications
Application	HIF-Hydroxylase Inhibitor, DMOG, CAS 89464-63-1, is a cell-permeable 2-oxoglutarate (2-OG) analog that acts as a competitive inhibitor against all 2-OG-dependent dioxygenases.

Biological Information
Purity	≥98% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity	Standard Handling
Storage	+2°C to +8°C
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
400091-50MGCN	04055977212389

Documentation

HIF-Hydroxylase Inhibitor, DMOG - CAS 89464-63-1 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

HIF-Hydroxylase Inhibitor, DMOG - CAS 89464-63-1 - Calbiochem 分析证书

标题	批号
400091	输入批号

参考

参考信息概述
Pollard, P.J., et al. 2008. Biochem. J. 416, 387. Chen, H., et al. 2006. Cancer Res. 66, 9009. Milkiewicz, M., et al. 2004. J. Physiol. 560, 21. Lando, D., et al. 2002. Science 295, 858. Jaakkola, P., et al. 2001. Science 292, 468.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	06-June-2015 JSW
Synonyms	N-(Methoxyoxoacetyl)-glycine methyl ester, Dimethyloxalylglycine, HIF Prolyl Hydroxylase Inhibitor I, HIF Aspartyl β-Hydroxylase Inhibitor, HIF Asparanginyl β-Hydroxylase Inhibitor
Description	A cell-permeable 2-OG (2-oxoglutarate) analog that is expected to act as a competitive inhibitor against all 2-OG-dependent dioxygenases. Effectively upregulates normoxia HIF-α transcription activity (effective conc. = 1 mM in cultures) by inhibiting HIF-PH- (HIF-α-prolyl hydroxylase) catalyzed ODD (oxygen-dependent degradation domain) Prolyl hydroxylation (Pro⁵⁶⁴ and Pro⁵³⁰ in HIF-1α and HIF-2α, respectively) and aspartyl/asparanginyl β-hydroxylase-catalyzed CAD Asp hydroxylation (Asn⁸⁰³ and Asn⁸⁵¹ in HIF-1α and HIF-2α, respectively), resulting in a blockage of pVHL (von Hippel-Lindau) ubiquitin ligase complex-mediated HIF-α degradation and a simultaneous promotion of HIF CAD (COOH-terminal activation domain) p300/CBP association. DMOG is also demonstrated to augment artery ligation-induced up-regulation of HIF-1α and FLK (by 100% and 40%, respectively, in 11 days; 8 mg/0.5 ml/animal/i.p.; q.o.d.) in muscle tissues in a murine ischaemic model in vivo.
Form	Pink-white to peach-white
CAS number	89464-63-1
Chemical formula	C₆H₉NO₅
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (50 mg/ml)
Storage	+2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Pollard, P.J., et al. 2008. Biochem. J. 416, 387. Chen, H., et al. 2006. Cancer Res. 66, 9009. Milkiewicz, M., et al. 2004. J. Physiol. 560, 21. Lando, D., et al. 2002. Science 295, 858. Jaakkola, P., et al. 2001. Science 292, 468.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Angiogenesis Inhibitors > Angiogenesis Inhibitors

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