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373210 Sigma-AldrichHDL Receptor SR-BI Inhibitor, BLT-1 - CAS 321673-30-7 - Calbiochem

The HDL Receptor SR-BI Inhibitor, BLT-1, also referenced under CAS 321673-30-7, controls the biological activity of HDL Receptor SR-B. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: Block Lipid Transport-1, 2-Hexyl-1-cyclopentanone thiosemicarbazone, 33M20

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
321673-30-7	C₁₂H₂₃N₃S

价格及供货情况

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Description
Overview	A cell-permeable thiosemicarbazone copper chelator that potently blocks the HDL receptor SR-BI- (scavenger receptor, class B, type I) mediated lipid uptake (IC₅₀ = 21 and 57 nM against DiI and CE uptake, respectively, from DiI-HDL and CE-HDL using hamster ldlA-7 cells expressing murine SR-BI) in a reversible manner, while exerting little effect toward intracellular membrane trafficking or cytoskeletal organization. BLT-1 chelates Cu⁺² in a 2:1 stoichiometric ratio and a half molar equivalent of CuCl₂ is shown to fully prevent zebrafish embryos from BLT-1-induced development defects, while BLT-1 can likewise be used to chelate excess amount of copper (>4 µM) and rescue embryos from copper toxicity.
Catalogue Number	373210
Brand Family	Calbiochem®
Synonyms	Block Lipid Transport-1, 2-Hexyl-1-cyclopentanone thiosemicarbazone, 33M20

References
References	Nieland, T.J.F., et al. 2008. Biochemistry 47, 460. Raldua, D., and Babin, P.J. 2007. Toxicol. Lett. 175, 1. Nieland, T.J.F., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 15422. Peterson, R.T., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 12965.

Product Information
CAS number	321673-30-7
Form	White solid
Hill Formula	C₁₂H₂₃N₃S
Chemical formula	C₁₂H₂₃N₃S
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥95% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
373210-25MGCN	04055977191608

Documentation

HDL Receptor SR-BI Inhibitor, BLT-1 - CAS 321673-30-7 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

HDL Receptor SR-BI Inhibitor, BLT-1 - CAS 321673-30-7 - Calbiochem 分析证书

标题	批号
373210	输入批号

参考

参考信息概述
Nieland, T.J.F., et al. 2008. Biochemistry 47, 460. Raldua, D., and Babin, P.J. 2007. Toxicol. Lett. 175, 1. Nieland, T.J.F., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 15422. Peterson, R.T., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 12965.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	12-April-2011 RFH
Synonyms	Block Lipid Transport-1, 2-Hexyl-1-cyclopentanone thiosemicarbazone, 33M20
Description	A cell-permeable thiosemicarbazone copper chelator that potently blocks the HDL receptor SR-BI- (scavenger receptor, class B, type I) mediated lipid uptake (IC₅₀ = 21 and 57 nM against DiI and CE uptake, respectively, from DiI-HDL and CE-HDL using hamster ldlA-7 cells expressing murine SR-BI) in a reversible manner, while exerting little effect toward intracellular membrane trafficking or cytoskeletal organization. BLT-1 chelates Cu⁺² in a 2:1 stoichiometric ratio and a half molar equivalent of CuCl₂ is shown to fully prevent zebrafish embryos from BLT-1-induced development defects, while BLT-1 can likewise be used to chelate excess amount of copper (>4 µM) and rescue embryos from copper toxicity.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	321673-30-7
Chemical formula	C₁₂H₂₃N₃S
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (100 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Nieland, T.J.F., et al. 2008. Biochemistry 47, 460. Raldua, D., and Babin, P.J. 2007. Toxicol. Lett. 175, 1. Nieland, T.J.F., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 15422. Peterson, R.T., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 12965.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > HDL Inhibitors

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