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345834 Sigma-AldrichGenistein, Soybean - CAS 446-72-0 - Calbiochem

A cell-permeable, reversible, substrate competitive inhibitor of protein tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC₅₀ = 2.6 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet
Citations

同义词: 4ʹ,5,7-Trihydroxyisoflavone

Primary Target: EGFR kinase

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
446-72-0	C₁₅H₁₀O₅

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
345834-20MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	玻璃瓶	20 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
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Description
Overview	A cell-permeable, reversible, substrate competitive inhibitor of protein tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC₅₀ = 2.6 µM). The inhibition is competitive with respect to ATP and non-competitive with respect to the phosphate acceptor. Has only a trivial effect on the activity of PKA and PKC (IC₅₀ > 350 µM). Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell cycle arrest and apoptosis in Jurkat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Also inhibits topoisomerase II activity in vitro.
Catalogue Number	345834
Brand Family	Calbiochem®
Synonyms	4ʹ,5,7-Trihydroxyisoflavone

References
References	Constantinou, A., and Huberman, E. 1995. Proc. Soc. Exp. Biol. Med. 208, 109. Wei, H., et al. 1995. Proc. Soc. Exp. Biol. Med. 208, 124. Wei, H., et al. 1995. Carcinogenesis 17, 73. Kobayashi, S., et al. 1994. J. Biol. Chem. 269, 9011. Migita, K., et al. 1994. J. Immunol. 153, 3457. Spinozzi, F., et al. 1994. Leuk. Res. 18, 431. Dhar, A., et al. 1990. Mol. Pharmacol. 37, 519. Hill, T.D., et al. 1990. Science 248, 1660. Dean, N.M., et al. 1989. Biochem. Biophys. Res. Commun. 165, 795. Akiyama, T., et al. 1987. J. Biol. Chem. 262, 5592.

References

Constantinou, A., and Huberman, E. 1995. Proc. Soc. Exp. Biol. Med. 208, 109.
Wei, H., et al. 1995. Proc. Soc. Exp. Biol. Med. 208, 124.
Wei, H., et al. 1995. Carcinogenesis 17, 73.
Kobayashi, S., et al. 1994. J. Biol. Chem. 269, 9011.
Migita, K., et al. 1994. J. Immunol. 153, 3457.
Spinozzi, F., et al. 1994. Leuk. Res. 18, 431.
Dhar, A., et al. 1990. Mol. Pharmacol. 37, 519.
Hill, T.D., et al. 1990. Science 248, 1660.
Dean, N.M., et al. 1989. Biochem. Biophys. Res. Commun. 165, 795.
Akiyama, T., et al. 1987. J. Biol. Chem. 262, 5592.

Product Information
CAS number	446-72-0
ATP Competitive	N
Form	White solid
Hill Formula	C₁₅H₁₀O₅
Chemical formula	C₁₅H₁₀O₅
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	EGFR kinase
Primary Target IC<sub>50</sub>	2.6 µM against autophosphorylation of epidermal growth factor receptor kinase
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	NR2392000

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
345834-20MGCN	04055977214376
345834-50MGCN	04055977214383

Documentation

Genistein, Soybean - CAS 446-72-0 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Genistein, Soybean - CAS 446-72-0 - Calbiochem 分析证书

标题	批号
345834	输入批号

参考

参考信息概述
Constantinou, A., and Huberman, E. 1995. Proc. Soc. Exp. Biol. Med. 208, 109. Wei, H., et al. 1995. Proc. Soc. Exp. Biol. Med. 208, 124. Wei, H., et al. 1995. Carcinogenesis 17, 73. Kobayashi, S., et al. 1994. J. Biol. Chem. 269, 9011. Migita, K., et al. 1994. J. Immunol. 153, 3457. Spinozzi, F., et al. 1994. Leuk. Res. 18, 431. Dhar, A., et al. 1990. Mol. Pharmacol. 37, 519. Hill, T.D., et al. 1990. Science 248, 1660. Dean, N.M., et al. 1989. Biochem. Biophys. Res. Commun. 165, 795. Akiyama, T., et al. 1987. J. Biol. Chem. 262, 5592.

参考信息概述

小册子

标题
Caspases and other Apoptosis Related Tools Brochure

引用

标题

Weijian Shao, Roy C. Orlando and Mouhamed S. Awayda. (2005) Bisphosphonates stimulate an endogenous nonselective cation channel in Xenopus oocytes: potential mechanism of action. American Journal of Physiology Cell Physiology 289, C248-C256.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	16-April-2010 JSW
Synonyms	4ʹ,5,7-Trihydroxyisoflavone
Description	A cell-permeable, reversible, substrate competitive inhibitor of protein tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC₅₀ = 2.6 µM). The inhibition is competitive with respect to ATP and non-competitive with respect to the phosphate acceptor. Inhibits tumor cell proliferation and induces tumor cell differentiation. Inhibits exogenous substrate phosphorylation by EGFR kinase and pp60^v-src with similar potencies (IC₅₀ = 20-25 µM). Has only a trivial effect on PKC and PKA (IC₅₀ >350 µM). Produces cell cycle arrest and apoptosis in Jurkat T-leukemia cells. Prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Also inhibits topoisomerase II activity in vitro. Blocks oxidative DNA damage in vitro.
Form	White solid
CAS number	446-72-0
RTECS	NR2392000
Chemical formula	C₁₅H₁₀O₅
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (200 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
Merck USA index	14, 4391
References	Constantinou, A., and Huberman, E. 1995. Proc. Soc. Exp. Biol. Med. 208, 109. Wei, H., et al. 1995. Proc. Soc. Exp. Biol. Med. 208, 124. Wei, H., et al. 1995. Carcinogenesis 17, 73. Kobayashi, S., et al. 1994. J. Biol. Chem. 269, 9011. Migita, K., et al. 1994. J. Immunol. 153, 3457. Spinozzi, F., et al. 1994. Leuk. Res. 18, 431. Dhar, A., et al. 1990. Mol. Pharmacol. 37, 519. Hill, T.D., et al. 1990. Science 248, 1660. Dean, N.M., et al. 1989. Biochem. Biophys. Res. Commun. 165, 795. Akiyama, T., et al. 1987. J. Biol. Chem. 262, 5592.
Citation	Weijian Shao, Roy C. Orlando and Mouhamed S. Awayda. (2005) Bisphosphonates stimulate an endogenous nonselective cation channel in Xenopus oocytes: potential mechanism of action. American Journal of Physiology Cell Physiology 289, C248-C256.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurobiology / Neurodegeneration > Amyloidogenesis Inhibitors

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Tyrosine Kinase (PTK) Inhibitors

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