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Has been characterized as one of the most important tumor-specific antigens in individuals with malignant melanoma. Reported to disrupt mitochondrial transmembrane potential and induce apoptosis in tumor cells by a caspase-independent mechanism. Antibodies to GD3 can induce partial remission of tumor growth in animals and in humans via enhancement of cytotoxic and proliferative responses of lymphocytes. M.W. 1577.0 (based on tricosanoyl - 23:0).
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
19-March-2008 JSW
Synonyms
Neu5Acα2,8Neu5Acα2,3Galβ1,4Glcβ1,1 Ceramide, 2NH₄
Description
Has been characterized as one of the most important tumor-specific antigens in individuals with malignant melanoma. Reported to disrupt mitochondrial transmembrane potential and induce apoptosis in tumor cells by a caspase-independent mechanism. Antibodies to GD3 can induce partial remission of tumor growth in animals and in humans via enhancement of cytotoxic and proliferative responses of lymphocytes. M.W. 1577.0 (based on tricosanoyl - 23:0).
Form
White solid
Chemical formula
C₇₀H₁₂₃N₃O₃₀ · 2NH₄
Structure formula
Purity
≥98% by TLC
Solubility
Chloroform:Methanol (2:1) or H₂O (1 mg/ml)
Storage
-20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C.
