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Useful as a differentiation marker of tumor cell growth. Protein kinase C inhibitor. Readily converted to GM1 by bacterial and mammalian neuraminidases without detergent or bile salts. Note: the moleculare weight is based on on stearoyl-18:0.
Catalogue Number
345736
Brand Family
Calbiochem®
Synonyms
Cer-Glc-Gal(NeuAc)-GalNAc-Gal-NeuAc ·2NH₄
References
References
Longee, D.C., et al. 1991. Acta Neuropathologica82, 45. Livingston, P.O., et al. 1987. Proc Natl. Acad. Sci. USA84, 2911. Kundu, S.K., and Scott, D.D. 1982. J. Chromato.232, 19. Wakomari, S. 1981. Annu. Rev. Biochem.50, 733.
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
05-September-2007 JSW
Synonyms
Cer-Glc-Gal(NeuAc)-GalNAc-Gal-NeuAc ·2NH₄
Description
Disialoganglioside prepared from bovine gray matter. Useful as a differentiation marker of tumor cell growth. Protein kinase C inhibitor. Readily converted to GM1 by bacterial and mammalian sialidases without detergent or bile salts. One mole yields 2 moles of sialic acid by thiobarbituric acid assay. The molecular weight is based on stearoyl-18:0.
Note: This product is not to be used for animal treatment, in vivo research, or in any other contact procedure with livestock.
Form
Lyophilized
Chemical formula
C₈₄H₁₄₆N₄O₃₉ · 2NH₄
Structure formula
Purity
≥98% by TLC
Solubility
Chloroform:Methanol (2:1) or DMSO. For use in aqueous systems, dissolve in a small amount of DMSO and then sonicate in buffer or medium, or dissolve the dried sample directly in aqueous buffers by sonication. Solutions may be filter sterilized.
Storage
-20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
Toxicity
Irritant
References
Longee, D.C., et al. 1991. Acta Neuropathologica82, 45. Livingston, P.O., et al. 1987. Proc Natl. Acad. Sci. USA84, 2911. Kundu, S.K., and Scott, D.D. 1982. J. Chromato.232, 19. Wakomari, S. 1981. Annu. Rev. Biochem.50, 733.
