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345700 Sigma-AldrichGanciclovir - CAS 82410-32-0 - Calbiochem

Ganciclovir, CAS 82410-32-0, is a nucleoside analog related to Acyclovir. Acts as a prodrug that is activated by phosphorylation. Inhibits the replication of cytomegalovirus (CMV; IC50 = 10 nM).

Ganciclovir - CAS 82410-32-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

分析证书
参考
Data Sheet

同义词: 9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine

Primary Target: Acts as a prodrug that is activated by phosphorylation

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
82410-32-0	C₉H₁₃N₅O₄

价格及供货情况

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Description
Overview	A nucleoside analog structurally related to Acyclovir (Cat. No. 114798). Acts as a prodrug that is activated by phosphorylation. Has been used in the study of “suicide” gene therapy in cancer research. Upon expression of a viral suicide gene encoding herpes simplex virus, thymidine kinase (TK), the non-toxic prodrug ganciclovir, is converted to an active phosphorylated analog that can be incorporated into the DNA of replicating eukaryotic cells, causing death of the malignant dividing cell. Causes an irreversible cell cycle arrest at the G₂/M checkpoint. Has also been used to study the loss of telomeres and to evaluate sensitivity of viruses to antiviral agents.
Catalogue Number	345700
Brand Family	Calbiochem®
Synonyms	9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine

References
References	Aghi, M., et al. 2000. J. Gene Med. 2, 148. Qiao, J., et al. 2000. Hum. Gene Ther. 11, 1569. Cannon, J.S., et al. 1999. J. Virol. 73, 4786. Rubsam, L.Z., et al. 1999. Cancer Res. 59, 669. Sprung, C.N., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 6781. Yamasaki, H., et al. 1999. C.R. Acad. Sci. III 322, 151. Halloran, P.J., and Fenton, R.G. 1998. Cancer Res. 58, 3855.

References

Aghi, M., et al. 2000. J. Gene Med. 2, 148.
Qiao, J., et al. 2000. Hum. Gene Ther. 11, 1569.
Cannon, J.S., et al. 1999. J. Virol. 73, 4786.
Rubsam, L.Z., et al. 1999. Cancer Res. 59, 669.
Sprung, C.N., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 6781.
Yamasaki, H., et al. 1999. C.R. Acad. Sci. III 322, 151.
Halloran, P.J., and Fenton, R.G. 1998. Cancer Res. 58, 3855.

Product Information
CAS number	82410-32-0
ATP Competitive	N
Form	White solid
Hill Formula	C₉H₁₃N₅O₄
Chemical formula	C₉H₁₃N₅O₄
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications
Application	Ganciclovir, CAS 82410-32-0, is a nucleoside analog related to Acyclovir. Acts as a prodrug that is activated by phosphorylation. Inhibits the replication of cytomegalovirus (CMV; IC50 = 10 nM).

Biological Information
Primary Target	Acts as a prodrug that is activated by phosphorylation
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	MF8407000

Safety Information
R Phrase	R: 46-60-61 May cause heritable genetic damage. May impair fertility. May cause harm to the unborn child.
S Phrase	S: 36/37/39-45-53 Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Avoid exposure - obtain special instructions before use.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Carcinogenic / Teratogenic
Storage	-20°C
Protect from Moisture	Protect from moisture
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
345700-50MGCN	04055977194500

Documentation

Ganciclovir - CAS 82410-32-0 - Calbiochem 分析证书

标题	批号
345700	输入批号

参考

参考信息概述
Aghi, M., et al. 2000. J. Gene Med. 2, 148. Qiao, J., et al. 2000. Hum. Gene Ther. 11, 1569. Cannon, J.S., et al. 1999. J. Virol. 73, 4786. Rubsam, L.Z., et al. 1999. Cancer Res. 59, 669. Sprung, C.N., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 6781. Yamasaki, H., et al. 1999. C.R. Acad. Sci. III 322, 151. Halloran, P.J., and Fenton, R.G. 1998. Cancer Res. 58, 3855.

参考信息概述

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	16-November-2007 JSW
Synonyms	9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine
Description	A nucleoside analog that is structurally related to Acyclovir (Cat. No. 114798). Acts as a pro-drug that is activated by phosphorylation. It has been used in the study of "suicide gene therapy" in cancer research. Upon expression of a viral suicide gene encoding herpes simplex virus thymidine kinase (TK), the non-toxic pro-drug is converted to the phosphorylated active analog and is incorporated into the DNA of replicating eukaryotic cells, causing death of the dividing malignant cells. Causes an irreversible cell cycle arrest at the G₂/M checkpoint. Has also been used to study the loss of telomers and to evaluate the sensitivity of viruses to anti-viral agents.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	82410-32-0
RTECS	MF8407000
Chemical formula	C₉H₁₃N₅O₄
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (5 mg/ml) or H₂O (2 mg/ml)
Storage	Protect from moisture -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Carcinogenic / Teratogenic
Merck USA index	14, 4363
References	Aghi, M., et al. 2000. J. Gene Med. 2, 148. Qiao, J., et al. 2000. Hum. Gene Ther. 11, 1569. Cannon, J.S., et al. 1999. J. Virol. 73, 4786. Rubsam, L.Z., et al. 1999. Cancer Res. 59, 669. Sprung, C.N., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 6781. Yamasaki, H., et al. 1999. C.R. Acad. Sci. III 322, 151. Halloran, P.J., and Fenton, R.G. 1998. Cancer Res. 58, 3855.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Anticancer Agents

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