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A dibenzofuran conjugated peptidomimetic (13-mer) that acts as an allosteric inhibitor of galectin-1 binding to cell surface glycans (IC50 = 3 µM). Shown to reduce the proliferation of endothelial cells and reduce vessel density in murine tumor models.
Catalogue Number
505823
Brand Family
Calbiochem®
Synonyms
SVQNvaKL-[DBF]-IIVKLNA
References
References
Dings, R.P., et al, 2013, J. Pharm. Exp. Ther.344, 589.
Dings, R.P., et al, 2013, J. Pharm. Exp. Ther.344, 589.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
06-December-2013 JSW
Synonyms
SVQNvaKL-[DBF]-IIVKLNA
Description
A dibenzofuran conjugated peptidomimetic (13-mer) that acts as an allosteric inhibitor of galectin-1 binding to cell surface glycans (IC50 = 3 µM). Shown to reduce the proliferation of endothelial cells and reduce vessel density in murine tumor models.
Form
White powder
Intert gas (Yes/No)
Packaged under inert gas
Chemical formula
C₈₃H₁₃₂N₁₈O₁₇
Peptide Sequence
SVQMKNva-[DBF]-IIVKLNA
Structure formula
Purity
≥98% by HPLC
Solubility
DMSO (10 mg/ml)
Storage
Protect from light
-20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
Dings, R.P., et al, 2013, J. Pharm. Exp. Ther.344, 589.
