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A water soluble GABA analog originally developed to treat epilepsy and neuropathic pain but is not believed to act on the same brain receptors. Gabapentin interacts with voltage-gated calcium channels in cortical neurons. It binds to the α2δ subunit (1 and 2) and has been found to reduce calcium currents after chronic but not acute application via an effect on trafficking of voltage-dependent calcium channels in the central nervous system.
Catalogue Number
508506
Brand Family
Calbiochem®
Synonyms
L-type Voltage Gated Ca2+ Channel Blocke, Gabapentin
References
References
Eroglu, C. et al. 2009. Cell.139, 380. Hendrich, J. et al. 2008. Proc. Natl. Acad. Sci. USA105, 3628. Davies, A. et al. 2007. Trends Pharmacol. Sci.28, 220.
Eroglu, C. et al. 2009. Cell.139, 380. Hendrich, J. et al. 2008. Proc. Natl. Acad. Sci. USA105, 3628. Davies, A. et al. 2007. Trends Pharmacol. Sci.28, 220.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
24-January-2014 JSW
Synonyms
L-type Voltage Gated Ca2+ Channel Blocke, Gabapentin
Description
A water soluble GABA analog originally developed to treat epilepsy and neuropathic pain but is not believed to act on the same brain receptors. Gabapentin interacts with voltage-gated calcium channels in cortical neurons. It binds to the α2δ subunit (1 and 2) and has been found to reduce calcium currents after chronic but not acute application via an effect on trafficking of voltage-dependent calcium channels in the central nervous system.
Form
White solid
CAS number
60142-96-3
Chemical formula
C₉H₁₇NO₂
Structure formula
Purity
≥98% by HPLC
Solubility
H₂O (100 mM)
Storage
Protect from light
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
Eroglu, C. et al. 2009. Cell.139, 380. Hendrich, J. et al. 2008. Proc. Natl. Acad. Sci. USA105, 3628. Davies, A. et al. 2007. Trends Pharmacol. Sci.28, 220.
