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361548 Sigma-AldrichGSK-3β Inhibitor VII - CAS 99-73-0 - Calbiochem

The GSK-3β Inhibitor VII, also referenced under CAS 99-73-0, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: α-4-Dibromoacetophenone, TPK I Inhibitor, Tau Protein Kinase I Inhibitor

Primary Target: GSK-3β

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
99-73-0	C₈H₆Br₂O

价格及供货情况

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Description
Overview	A phenyl α-bromomethyl ketone compound that acts as a cell-permeable, and non-ATP competitive inhibitor of GSK-3β (IC₅₀ = 0.5 µM). This reactive alkylating agent is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 µM.
Catalogue Number	361548
Brand Family	Calbiochem®
Synonyms	α-4-Dibromoacetophenone, TPK I Inhibitor, Tau Protein Kinase I Inhibitor

References
References	Conde, S., et al. 2003. J. Med. Chem. 46, 4631.

Product Information
CAS number	99-73-0
ATP Competitive	N
Form	White solid
Hill Formula	C₈H₆Br₂O
Chemical formula	C₈H₆Br₂O
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	GSK-3β
Primary Target IC<sub>50</sub>	0.5 µM against GSK-3β
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	AM6950000

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped with Blue Ice or with Dry Ice
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Protect from Moisture	Protect from moisture
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
361548-5MGCN	04055977214048

Documentation

GSK-3β Inhibitor VII - CAS 99-73-0 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

GSK-3β Inhibitor VII - CAS 99-73-0 - Calbiochem 分析证书

标题	批号
361548	输入批号

参考

参考信息概述
Conde, S., et al. 2003. J. Med. Chem. 46, 4631.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	01-July-2008 RFH
Synonyms	α-4-Dibromoacetophenone, TPK I Inhibitor, Tau Protein Kinase I Inhibitor
Description	A phenyl α-bromomethyl ketone compound that acts as a cell-permeable, selective, and non-ATP competitive inhibitor of GSK-3β (IC₅₀ = 500 nM). Does not affect the activity of PKA even at concentrations as high as 100 µM.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	99-73-0
RTECS	AM6950000
Chemical formula	C₈H₆Br₂O
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (5 mg/ml)
Storage	Protect from moisture Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Conde, S., et al. 2003. J. Med. Chem. 46, 4631.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Glycogen Synthase Kinase (GSK) Inhibitors

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