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361540 Sigma-AldrichGSK-3β Inhibitor I - CAS 327036-89-5 - Calbiochem

The GSK-3β Inhibitor I, also referenced under CAS 327036-89-5, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet

同义词: TDZD-8, 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione

Primary Target: Gsk-3β

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
327036-89-5	C₁₀H₁₀N₂SO₂

价格及供货情况

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Description
Overview	A thiadiazolidinone (TDZD) analog that acts as a highly selective, non-ATP competitive inhibitor of GSK-3β (IC₅₀ = 2 µM). Inhibits Flt-3 and PKC activities (IC₅₀ = 673 nM and 1.4-5.5 µM, respectively). Does not significantly affect the activities of Cdk-1/cyclin B, CK-II, and PKA, (IC₅₀ > 100 µM). Binds to the active site of GSK-3β.
Catalogue Number	361540
Brand Family	Calbiochem®
Synonyms	TDZD-8, 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione

References
References	Guzman, M.L., et al. 2007. Blood 110, 4436. Barry, F.A., et al. 2003. FEBS Lett. 553, 173. Martinez, A., et al. 2002. J. Med. Chem. 45, 1292.

Product Information
CAS number	327036-89-5
ATP Competitive	N
Form	White to off-white solid
Hill Formula	C₁₀H₁₀N₂SO₂
Chemical formula	C₁₀H₁₀N₂SO₂
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Gsk-3β
Primary Target IC<sub>50</sub>	2 µM, 673 nM, 1.4-5.5 µM, against GSK-3β, Flt-3, and PKC activities, respectively
Purity	≥ 95% by HPLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
361540-5MGCN	07790788049584

Documentation

GSK-3β Inhibitor I - CAS 327036-89-5 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

GSK-3β Inhibitor I - CAS 327036-89-5 - Calbiochem 分析证书

标题	批号
361540	输入批号

参考

参考信息概述
Guzman, M.L., et al. 2007. Blood 110, 4436. Barry, F.A., et al. 2003. FEBS Lett. 553, 173. Martinez, A., et al. 2002. J. Med. Chem. 45, 1292.

小册子

标题
Alzheimer's Disease Brochure & Technical Guide

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	12-April-2011 RFH
Synonyms	TDZD-8, 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
Description	A cell-permeable, thiadiazolidinone (TDZD) analog that acts as a highly selective, non-ATP-competitive inhibitor of GSK-3β (IC₅₀ = 2 µM). Inhibits Flt-3 and PKC activities (IC₅₀ = 673 nM and 1.4-5.5 µM, respectively). Does not significantly affect the activities of Cdk1/cyclin B, CK-II, PKA, or PKC (IC₅₀ >100 µM). Shown to inhibit collagen- and thrombin-induced platelet aggregation.
Form	White to off-white solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	327036-89-5
Chemical formula	C₁₀H₁₀N₂SO₂
Structure formula
Purity	≥ 95% by HPLC
Solubility	DMSO (10 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Guzman, M.L., et al. 2007. Blood 110, 4436. Barry, F.A., et al. 2003. FEBS Lett. 553, 173. Martinez, A., et al. 2002. J. Med. Chem. 45, 1292.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Glycogen Synthase Kinase (GSK) Inhibitors

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