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371724 Sigma-AldrichGPR119 Agonist, AS1269574 - CAS 330981-72-1 - Calbiochem

The GPR119 Agonist, AS1269574, also referenced under CAS 330981-72-1, controls the biological activity of GPR119. This small molecule/inhibitor is primarily used for Biochemicals applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 2-((2-(4-Bromophenyl)-6-methylpyrimidin-4-yl)amino)ethanol, G-Protein Coupled Receptor 119 Agonist, GPCR2 Agonist, MGC119957 Agonist, SNORF25 Agonist

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
330981-72-1	C₁₃H₁₄BrN₃O

价格及供货情况

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Description
Overview	A pyrimidine compound that acts as an effective GPR119 agonist (EC₅₀ = 2.5 µM in stimulating cAMP in hGPR119-expressing HEK293 cells) and reportedly exhibits no activity toward β-adrenergic or GLP-1 receptors. Shown to enhance 16.8 mM glucose-induced insulin secretion from murine MIN-6 β-cells (mU/20 min = 0.44 and 0.22, respectively, with or without 10 µM AS1269574) in vitro and improve glucose tolerance in normal mice (100 mg/kg; p.o.) without any significant hypoglycemic effect in vivo.
Catalogue Number	371724
Brand Family	Calbiochem®
Synonyms	2-((2-(4-Bromophenyl)-6-methylpyrimidin-4-yl)amino)ethanol, G-Protein Coupled Receptor 119 Agonist, GPCR2 Agonist, MGC119957 Agonist, SNORF25 Agonist

References
References	Yoshida, S., et cl. 2010. Biochem. Biophys. Res. Commun. 400, 437.

Product Information
CAS number	330981-72-1
Form	Amber solid
Hill Formula	C₁₃H₁₄BrN₃O
Chemical formula	C₁₃H₁₄BrN₃O
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥99% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity	Regulatory Review
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
371724-10MGCN	04055977213263

Documentation

GPR119 Agonist, AS1269574 - CAS 330981-72-1 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

GPR119 Agonist, AS1269574 - CAS 330981-72-1 - Calbiochem 分析证书

标题	批号
371724	输入批号

参考

参考信息概述
Yoshida, S., et cl. 2010. Biochem. Biophys. Res. Commun. 400, 437.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	24-September-2012 JSW
Synonyms	2-((2-(4-Bromophenyl)-6-methylpyrimidin-4-yl)amino)ethanol, G-Protein Coupled Receptor 119 Agonist, GPCR2 Agonist, MGC119957 Agonist, SNORF25 Agonist
Description	A pyrimidine compound that acts as an effective GPR119 agonist (EC₅₀ = 2.5 µM in stimulating cAMP in hGPR119-expressing HEK293 cells) and reportedly exhibits no activity toward β-adrenergic or GLP-1 receptors. Shown to enhance 16.8 mM glucose-induced insulin secretion from murine MIN-6 β-cells (mU/20 min = 0.22, 0.29, 0.44, respectively, with 0, 1, 10 µM AS1269574) in vitro and improve glucose tolerance in normal mice (26% decrease and 60% increase, respectively, of control blood glucose and insulin AUC_0-1h in OGTT; 100 mg/kg; p.o.) without affecting basal blood glucose level in either fed or fasting mice in vivo.
Form	Amber solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	330981-72-1
Chemical formula	C₁₃H₁₄BrN₃O
Structure formula
Purity	≥99% by HPLC
Solubility	DMSO (>10 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Regulatory Review
References	Yoshida, S., et cl. 2010. Biochem. Biophys. Res. Commun. 400, 437.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Activators > G-Protein Activators

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