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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

364205 Sigma-AldrichGM 6001 - CAS 142880-36-2 - Calbiochem

GM 6001, CAS 142880-36-2, is a potent, cell-permeable, broad-spectrum inhibitor of MMPs (Ki = 400 pM for MMP-1; 500 pM for MMP-2; 27 nM for MMP-3; 100 pM for MMP-8; and 200 pM for MMP-9).

GM 6001 - CAS 142880-36-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet
Citations

同义词: Galardin, N-[(2R)-2-(Hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan Methylamide

Primary Target: MMP-1

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
142880-36-2	C₂₀H₂₈N₄O₄

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
364205-1MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	1 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
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Description
Overview	A potent, cell-permeable, broad-spectrum hydroxamic acid inhibitor of matrix metalloproteinases (MMPs); (K_i = 400 pM for MMP-1; K_i = 500 pM for MMP-2; K_i = 27 nM for MMP-3; K_i= 100 pM for MMP-8; and K_i = 200 pM for MMP-9). Prevents the release of TNF-α in vivo and in vitro and abrogates endotoxin-induced lethality in mice. A 10 mM (1 mg/257 µl) solution of GM6001 (Cat. No. 364206) in DMSO is also available.
Catalogue Number	364205
Brand Family	Calbiochem®
Synonyms	Galardin, N-[(2R)-2-(Hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan Methylamide

References
References	Solorzano, C.C., et al. 1997. Shock 7, 427. Galardy, R.E., et al. 1994. Ann. NY Acad. Sci. 732, 315. Galardy, R.E., et al. 1994. Cancer Res. 54, 4715. Galardy, R.E. 1993. Drugs Future 18, 1109. Grobelny, D., et al. 1992. Biochemistry 31, 7152.

Product Information
CAS number	142880-36-2
ATP Competitive	N
Form	Off-white solid
Hill Formula	C₂₀H₂₈N₄O₄
Chemical formula	C₂₀H₂₈N₄O₄
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications
Application	GM 6001, CAS 142880-36-2, is a potent, cell-permeable, broad-spectrum inhibitor of MMPs (Ki = 400 pM for MMP-1; 500 pM for MMP-2; 27 nM for MMP-3; 100 pM for MMP-8; and 200 pM for MMP-9).

Biological Information
Primary Target	MMP-1
Primary Target K<sub>i</sub>	400 pM for MMP-1; 500 pM for MMP-2; 27 nM for MMP-3; 100 pM for MMP-8; 200 pM for MMP-9
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
364205-1MGCN	04055977213744
364205-5MGCN	04055977213799

Documentation

GM 6001 - CAS 142880-36-2 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

GM 6001 - CAS 142880-36-2 - Calbiochem 分析证书

标题	批号
364205	输入批号

参考

参考信息概述
Solorzano, C.C., et al. 1997. Shock 7, 427. Galardy, R.E., et al. 1994. Ann. NY Acad. Sci. 732, 315. Galardy, R.E., et al. 1994. Cancer Res. 54, 4715. Galardy, R.E. 1993. Drugs Future 18, 1109. Grobelny, D., et al. 1992. Biochemistry 31, 7152.

引用

标题

K. Fredriksson, et al. (2006) Red blood cells increase secretion of matrix metalloproteinases from human lung fibroblasts in vitro. American Journal of Physiology Lung Cellular and Molecular Physiology 290, L326-L333.

Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.

IM, E., et al. 2005. Molecular Biology of the Cell 16, 3488.

Daniel W. Lambert, et al. (2005) Tumor Necrosis Factor- Convertase (ADAM17) Mediates Regulated Ectodomain Shedding of the Severe-acute Respiratory Syndrome-Coronavirus (SARS-CoV) Receptor, Angiotensin-converting Enzyme-2 (ACE2). Journal of Biological Chemistry 280, 30113-30119.

Haili Su, et al. (2005) Noninvasive targeted imaging of matrix metalloproteinase activation in a murine model of postinfarction remodeling. Circulation 112, 3157-3167.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	07-April-2008 RFH
Synonyms	Galardin, N-[(2R)-2-(Hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan Methylamide
Description	A cell-permeable, potent broad-spectrum hydroxamic acid inhibitor of matrix metalloproteinases (MMPs). [K_i = 0.4 nM for skin fibroblast collagenase (MMP-1); K_i = 0.5 nM for gelatinase A (MMP-2); K_i = 27 nM for stromelysin (MMP-3); K_i = 0.1 nM for neutrophil collagenase (MMP-8); and K_i = 0.2 nM for gelatinase B (MMP-9)]. Also prevents the release of TNF-α in vivo and in vitro and abrogates endotoxin-induced lethality in mice.
Form	Off-white solid
CAS number	142880-36-2
Chemical formula	C₂₀H₂₈N₄O₄
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (5 mg/ml)
Storage	-20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Solorzano, C.C., et al. 1997. Shock 7, 427. Galardy, R.E., et al. 1994. Ann. NY Acad. Sci. 732, 315. Galardy, R.E., et al. 1994. Cancer Res. 54, 4715. Galardy, R.E. 1993. Drugs Future 18, 1109. Grobelny, D., et al. 1992. Biochemistry 31, 7152.
Citation	K. Fredriksson, et al. (2006) Red blood cells increase secretion of matrix metalloproteinases from human lung fibroblasts in vitro. American Journal of Physiology Lung Cellular and Molecular Physiology 290, L326-L333. Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680. IM, E., et al. 2005. Molecular Biology of the Cell 16, 3488. Daniel W. Lambert, et al. (2005) Tumor Necrosis Factor- Convertase (ADAM17) Mediates Regulated Ectodomain Shedding of the Severe-acute Respiratory Syndrome-Coronavirus (SARS-CoV) Receptor, Angiotensin-converting Enzyme-2 (ACE2). Journal of Biological Chemistry 280, 30113-30119. Haili Su, et al. (2005) Noninvasive targeted imaging of matrix metalloproteinase activation in a murine model of postinfarction remodeling. Circulation 112, 3157-3167.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Matrix Metalloproteinase (MMP) Inhibitors

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