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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

371818 Sigma-AldrichG-Protein βγ Binding Peptide, mSIRK - Calbiochem

A cell-permeable, N-myristoylated G-protein βγ selective binding peptide that disrupts the interaction between α and βγ subunits and promotes the α subunit dissociation without stimulating nucleotide exchange.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: mSIRK, myr-SIRKALNILGYPDYD-OH

Primary Target: N-myristoylated G-protein βγ selective binding

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概述

Replacement Information

重要规格表

Empirical Formula
C₉₃H₁₅₀N₂₀O₂₅

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
371818-1MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	玻璃瓶	1 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
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Description
Overview	A cell-permeable, N-myristoylated G-protein βγ selective binding peptide that disrupts the interaction between α and βγ subunits and promotes the α subunit dissociation without stimulating nucleotide exchange. Shown to cause a rapid activation of ERK1/2 (EC₅₀ ~ 2.5 - 5 µM) in rat arterial smooth muscle and Rat2 cells. Also promotes the phosphorylation of JNK and p38 MAP kinase, phospholipase C and causes Ca²⁺ release from internal stores. Negative control is also available (Cat. No. 371820).
Catalogue Number	371818
Brand Family	Calbiochem®
Synonyms	mSIRK, myr-SIRKALNILGYPDYD-OH

References
References	Goubaeva, F., et al. 2003. J. Biol. Chem. 278, 19634. Scott, J.K., et al. 2001. EMBO J. 20, 767.

Product Information
ATP Competitive	N
Form	Lyophilized
Formulation	Supplied as a trifluoroacetate salt.
Hill Formula	C₉₃H₁₅₀N₂₀O₂₅
Chemical formula	C₉₃H₁₅₀N₂₀O₂₅
Hygroscopic	Hygroscopic
Reversible	N
Quality Level	MQ100

Applications

Biological Information
Primary Target	N-myristoylated G-protein βγ selective binding
Primary Target IC<sub>50</sub>	EC50 ~ 2.5 - 5 µM in activation of ERK1/2 in rat arterial smooth muscle and Rat2 cells
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y
Peptide Sequence	Myr-N-Ser-Ile-Arg-Lys-Ala-Leu-Asn-Ile-Leu-Gly-Tyr-Pro-Asp-Tyr-Asp-OH

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
371818-1MGCN	04055977213423
371818-5MGCN	04055977213430

Documentation

G-Protein βγ Binding Peptide, mSIRK - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

G-Protein βγ Binding Peptide, mSIRK - Calbiochem 分析证书

标题	批号
371818	输入批号

参考

参考信息概述
Goubaeva, F., et al. 2003. J. Biol. Chem. 278, 19634. Scott, J.K., et al. 2001. EMBO J. 20, 767.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	07-July-2008 RFH
Synonyms	mSIRK, myr-SIRKALNILGYPDYD-OH
Description	A cell-permeable, N-myristoylated G-protein βγ selective binding peptide that disrupts the interaction between α and βγ subunits and promotes α subunit dissociation without stimulating nucleotide exchange. Reported to cause a rapid activation of ERK1/2 (EC₅₀ ~2.5-5 µM) in RASM (rat arterial smooth muscle) and Rat2 cells. Promotes the phosphorylation of JNK and p38 MAP kinase. Also increases phospholipase C activity and causes Ca²⁺ release from internal stores.
Form	Lyophilized
Formulation	Supplied as a trifluoroacetate salt.
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₉₃H₁₅₀N₂₀O₂₅
Peptide Sequence	Myr-N-Ser-Ile-Arg-Lys-Ala-Leu-Asn-Ile-Leu-Gly-Tyr-Pro-Asp-Tyr-Asp-OH
Purity	≥95% by HPLC
Solubility	DMSO (5 mg/ml)
Storage	+2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C
Toxicity	Standard Handling
References	Goubaeva, F., et al. 2003. J. Biol. Chem. 278, 19634. Scott, J.K., et al. 2001. EMBO J. 20, 767.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Activators > G-Protein Activators

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