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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

344930 Sigma-AldrichFurin Inhibitor I - Calbiochem

Furin Inhibitor I, is a peptidyl chloromethylketone that binds to the catalytic site of furin and blocks its activity.

Furin Inhibitor I - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: Decanoyl-RVKR-CMK

Primary Target: viral glycoproteins

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概述

Replacement Information

重要规格表

Empirical Formula
C₃₄H₆₆ClN₁₁O₅

价格及供货情况

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Description
Overview	A peptidyl chloromethylketone that binds to the catalytic site of furin and blocks its activity. Hence, it can be used as a high specificity cleavage inhibitor of viral glycoproteins and blocker of viral replication. Reported to block the shedding of MT5-MMP by furin and prevent the activation of MT5-MMP. Also shown to reduce the pro-peptide cleavage of BACE (β-site APP-cleaving enzyme).
Catalogue Number	344930
Brand Family	Calbiochem®
Synonyms	Decanoyl-RVKR-CMK

References
References	Sugrue, R.J., et al. 2001. J. Gen. Virol. 82, 1375. Wang, X., and Pei, D. 2001. J. Biol. Chem. 276, 35953. Capell, A., et al. 2000. J. Biol. Chem. 275, 30849. Denault, J.B., et al. 1995. FEBS Lett. 362, 276. Denault, J.B., et al. 1995. J. Cardiovasc. Pharmacol. 26, S47. Garten, W., et al. 1994. Biochimie 76, 217. Hallenberger, S., et al. 1992. Nature 360, 358. Stieneke-Gröber, A., et al. 1992. EMBO J. 11, 2407.

References

Sugrue, R.J., et al. 2001. J. Gen. Virol. 82, 1375.
Wang, X., and Pei, D. 2001. J. Biol. Chem. 276, 35953.
Capell, A., et al. 2000. J. Biol. Chem. 275, 30849.
Denault, J.B., et al. 1995. FEBS Lett. 362, 276.
Denault, J.B., et al. 1995. J. Cardiovasc. Pharmacol. 26, S47.
Garten, W., et al. 1994. Biochimie 76, 217.
Hallenberger, S., et al. 1992. Nature 360, 358.
Stieneke-Gröber, A., et al. 1992. EMBO J. 11, 2407.

Product Information
Form	Off-white solid
Formulation	Supplied as a trifluoroacetate salt.
Hill Formula	C₃₄H₆₆ClN₁₁O₅
Chemical formula	C₃₄H₆₆ClN₁₁O₅
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	viral glycoproteins
Purity	≥90% by HPLC

Physicochemical Information
Cell permeable	Y
Peptide Sequence	Decanoyl-Arg-Val-Lys-Arg-CMK

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Moisture	Protect from moisture
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
344930-1MGCN	04055977194371

Documentation

Furin Inhibitor I - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Furin Inhibitor I - Calbiochem 分析证书

标题	批号
344930	输入批号

参考

参考信息概述
Sugrue, R.J., et al. 2001. J. Gen. Virol. 82, 1375. Wang, X., and Pei, D. 2001. J. Biol. Chem. 276, 35953. Capell, A., et al. 2000. J. Biol. Chem. 275, 30849. Denault, J.B., et al. 1995. FEBS Lett. 362, 276. Denault, J.B., et al. 1995. J. Cardiovasc. Pharmacol. 26, S47. Garten, W., et al. 1994. Biochimie 76, 217. Hallenberger, S., et al. 1992. Nature 360, 358. Stieneke-Gröber, A., et al. 1992. EMBO J. 11, 2407.

参考信息概述

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	27-June-2008 RFH
Synonyms	Decanoyl-RVKR-CMK
Description	A peptidyl chloromethylketone that binds irreversibly to the catalytic site of furin and blocks its activity. Hence, it can be used as a high specificity cleavage inhibitor of viral glycoproteins and blocker viral replication. Reported to block the shedding of MT5-MMP by furin and prevent the activation of MT5-MMP. Completely inhibits the cleavage of Boc-RVRR-AMC (50 µM) by purified furin or PACE4. Also inhibits the activity of endothelin converting enzyme and reduces the pro-peptide cleavage of BACE (β-site APP-cleaving enzyme).
Form	Off-white solid
Formulation	Supplied as a trifluoroacetate salt.
Chemical formula	C₃₄H₆₆ClN₁₁O₅
Peptide Sequence	Decanoyl-Arg-Val-Lys-Arg-CMK
Structure formula
Purity	≥90% by HPLC
Solubility	DMSO or Methanol (1 mg/ml)
Storage	Protect from moisture -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity	Standard Handling
References	Sugrue, R.J., et al. 2001. J. Gen. Virol. 82, 1375. Wang, X., and Pei, D. 2001. J. Biol. Chem. 276, 35953. Capell, A., et al. 2000. J. Biol. Chem. 275, 30849. Denault, J.B., et al. 1995. FEBS Lett. 362, 276. Denault, J.B., et al. 1995. J. Cardiovasc. Pharmacol. 26, S47. Garten, W., et al. 1994. Biochimie 76, 217. Hallenberger, S., et al. 1992. Nature 360, 358. Stieneke-Gröber, A., et al. 1992. EMBO J. 11, 2407.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Furin Inhibitors

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