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344847
Sigma-AldrichFumitremorgin C, Aspergillus. fumigatus - CAS 118974-02-0 - Calbiochem
Fumitremorgin C, Aspergillus. Fumigatus, CAS 118974-02-0, is a cell-permeable chemo-sensitizing agent that inhibits BCRP/ABCG2 multidrug transport activity.
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MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
A cell-permeable indolyldiketopiperazinyl mycotoxin that inhibits BCRP/ABCG2 (breast cancer resistance protein/ATP-binding cassette G2) multidrug transport activity. Also acts as a potent and specific chemosenzitizing agent.
Catalogue Number
344847
Brand Family
Calbiochem®
Synonyms
NSC719655, FTC
References
References
Allen, J.D., et al. 2002. Mol. Cancer Ther.1, 417. Ozvegy, C., et al. 2001. Biochem. Biophys. Res. Commun.285, 111. Rabindran, S.K., et al. 2000. Cancer Res.60, 47. Rabindran, S.K., et al. 1998. Cancer Res.58, 5850. Cole, R.J., et al. 1977. J. Agric. Food Chem.25, 826.
Fumitremorgin C, Aspergillus. Fumigatus, CAS 118974-02-0, is a cell-permeable chemo-sensitizing agent that inhibits BCRP/ABCG2 multidrug transport activity.
Biological Information
Primary Target
BCRP/ABCG2 (breast cancer resistance protein/ATP-binding cassette G2)
Purity
≥95% by HPLC
Physicochemical Information
Cell permeable
Y
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Toxic
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
+2°C to +8°C
Protect from Light
Protect from light
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas
Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号
GTIN
344847-250UGCN
04055977214864
Documentation
Fumitremorgin C, Aspergillus. fumigatus - CAS 118974-02-0 - Calbiochem MSDS
Fumitremorgin C, Aspergillus. fumigatus - CAS 118974-02-0 - Calbiochem 分析证书
标题
批号
344847
参考
参考信息概述
Allen, J.D., et al. 2002. Mol. Cancer Ther.1, 417. Ozvegy, C., et al. 2001. Biochem. Biophys. Res. Commun.285, 111. Rabindran, S.K., et al. 2000. Cancer Res.60, 47. Rabindran, S.K., et al. 1998. Cancer Res.58, 5850. Cole, R.J., et al. 1977. J. Agric. Food Chem.25, 826.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
05-May-2008 RFH
Synonyms
NSC719655, FTC
Description
A cell-permeable indolyldiketopiperazinyl mycotoxin that inhibits the ATPase and multidrug resistance activity of BCRP/ABCG2 (breast cancer resistance protein/ATP-binding cassette G2) without affecting the activity of MDR1. Also acts as a potent and specific chemosenzitizing agent. Suggested concentration for cell inhibition studies: ~1-5 µM.
Form
Lyophilized
Intert gas (Yes/No)
Packaged under inert gas
CAS number
118974-02-0
Chemical formula
C₂₂H₂₅N₃O₃
Structure formula
Purity
≥95% by HPLC
Solubility
DMSO (10 mg/ml) or Ethanol (5 mg/ml)
Storage
Protect from light
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Toxic
References
Allen, J.D., et al. 2002. Mol. Cancer Ther.1, 417. Ozvegy, C., et al. 2001. Biochem. Biophys. Res. Commun.285, 111. Rabindran, S.K., et al. 2000. Cancer Res.60, 47. Rabindran, S.K., et al. 1998. Cancer Res.58, 5850. Cole, R.J., et al. 1977. J. Agric. Food Chem.25, 826.
