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344270 Sigma-AldrichForskolin, Coleus forskohlii - CAS 66575-29-9 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet
Citations

同义词: 7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxy-labd-14-en-11-one, Colforsin

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
66575-29-9	C₂₂H₃₄O₇

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
344270-10MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	10 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
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Description
Overview	The major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii. At low doses, it acts as a positive inotropic agent. At higher doses, it serves as a hypotensive and vasodilatory agent due to its actions as a smooth muscle relaxant. No major side effects are observed at effective doses. Forskolins pharmacological activities are due to its activation of adenylate cyclase (EC₅₀ = 4 µM), resulting in increased cAMP levels. The exact mechanism of forskolins positive inotropic effect is unknown but may be related to a cAMP-dependent increase in Na⁺ permeability that results in indirect augmentation of Ca²⁺ release. Inhibits MAP kinase in rat renal mesangial cells (IC₅₀ = 25 µM). Also acts as a Hh pathway antagonist. Shown to inhibit apoptosis in cerebellar granule cells and to induce apoptosis in resting human B lymphocytes.
Catalogue Number	344270
Brand Family	Calbiochem®
Synonyms	7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxy-labd-14-en-11-one, Colforsin

References
References	D'Orazio, J.A., et al. 2006. Nature 443, 340. Noveen, A., et al. 1996. Biochem. Biophys. Res. Commun. 219, 180. Galli, C., et al. 1995. J. Neurosci. 15, 1172. Li, X., et al. 1995. Am. J. Physiol. 269, C986. Lomo, J., et al. 1995. J. Immunol. 154, 1634. Uneyama, H., et al. 1993. J. Biol. Chem. 268, 168. Laurenza, A., et al. 1989. Trends Pharmacol. Sci. 10, 442. Adashi, E.Y., and Resnick, C.E. 1986. J. Cell. Biochem. 31, 217. Seamon, K.B., and Daly, J.W. 1986. Adv. Cyclic Nucleotide Protein Phosphorylation Res. 20, 1. Huang, R., et al. 1982. Cyclic Nucleotide Res. 8, 385. Metzger, H., and Lindner, E. 1981. IRCS Med. Sci. Biochem. Cardiovasc. System Pharmacol. 9, 99.

References

D'Orazio, J.A., et al. 2006. Nature 443, 340.
Noveen, A., et al. 1996. Biochem. Biophys. Res. Commun. 219, 180.
Galli, C., et al. 1995. J. Neurosci. 15, 1172.
Li, X., et al. 1995. Am. J. Physiol. 269, C986.
Lomo, J., et al. 1995. J. Immunol. 154, 1634.
Uneyama, H., et al. 1993. J. Biol. Chem. 268, 168.
Laurenza, A., et al. 1989. Trends Pharmacol. Sci. 10, 442.
Adashi, E.Y., and Resnick, C.E. 1986. J. Cell. Biochem. 31, 217.
Seamon, K.B., and Daly, J.W. 1986. Adv. Cyclic Nucleotide Protein Phosphorylation Res. 20, 1.
Huang, R., et al. 1982. Cyclic Nucleotide Res. 8, 385.
Metzger, H., and Lindner, E. 1981. IRCS Med. Sci. Biochem. Cardiovasc. System Pharmacol. 9, 99.

Product Information
CAS number	66575-29-9
ATP Competitive	N
Form	White to off-white crystalline solid
Hill Formula	C₂₂H₃₄O₇
Chemical formula	C₂₂H₃₄O₇
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Adenylate cyclase
Primary Target IC<sub>50</sub>	25 µM inhibiting MAP kinase in rat renal mesangial cells; EC50 = 4 µM for activation of adenylate cyclase
Purity	≥99% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	QL6150000

Safety Information
R Phrase	R: 21 Harmful in contact with skin.
S Phrase	S: 36 Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Harmful
Storage	+15°C to +30°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, store in the refrigerator (4°C). DMSO stock solutions are stable for up to 4 months at 4°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
344270-10MGCN	07790788049294
344270-25MGCN	04055977215359
344270-50MGCN	04055977215366

Documentation

Forskolin, Coleus forskohlii - CAS 66575-29-9 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Forskolin, Coleus forskohlii - CAS 66575-29-9 - Calbiochem 分析证书

标题	批号
344270	输入批号

参考

参考信息概述
D'Orazio, J.A., et al. 2006. Nature 443, 340. Noveen, A., et al. 1996. Biochem. Biophys. Res. Commun. 219, 180. Galli, C., et al. 1995. J. Neurosci. 15, 1172. Li, X., et al. 1995. Am. J. Physiol. 269, C986. Lomo, J., et al. 1995. J. Immunol. 154, 1634. Uneyama, H., et al. 1993. J. Biol. Chem. 268, 168. Laurenza, A., et al. 1989. Trends Pharmacol. Sci. 10, 442. Adashi, E.Y., and Resnick, C.E. 1986. J. Cell. Biochem. 31, 217. Seamon, K.B., and Daly, J.W. 1986. Adv. Cyclic Nucleotide Protein Phosphorylation Res. 20, 1. Huang, R., et al. 1982. Cyclic Nucleotide Res. 8, 385. Metzger, H., and Lindner, E. 1981. IRCS Med. Sci. Biochem. Cardiovasc. System Pharmacol. 9, 99.

参考信息概述

小册子

标题
Activators and Inhibitors of Adenylate Cyclase Technical Bulletin

引用

标题

Ryan W Carlin, et al. (2006) PVD9902, a porcine vas deferens epithelial cell line that exhibits neurotransmitter-stimulated anion secretion and expresses numerous HCO3- transporters. American Journal of Physiology Cell Physiology 290, C1560-C1571.

Iwona Bogacka, et al. (2005) Structural and functional consequences of mitochondrial biogenesis in human adipocytes in vitro. Journal of Clinical Endocrinology and Metabolism in press,.

Michael J. Cross, et al. (2002) The Shb Adaptor Protein Binds to Tyrosine 766 in the FGFR-1 and Regulates the Ras/MEK/MAPK Pathway via FRS2 Phosphorylation in Endothelial Cells. Molecular Biology of the Cell 13, 2881-2893.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	20-November-2008 JSW
Synonyms	7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxy-labd-14-en-11-one, Colforsin
Description	A cardioactive diterpene isolated from the Indian plant Coleus forskolii. At low doses, acts as a positive inotropic agent in dogs, cats, spontaneously hypertensive and normal rats, and isolated guinea pig heart. At higher doses, acts as a hypotensive and vasodilatory agent due to its action as a smooth muscle relaxant. No major side effects are observed at effective doses. Rapid and reversible activator of adenylate cyclase (EC₅₀ = 4 µM) in membranes and intact cells. Does not affect the activity of guanylate cyclase or cyclic nucleotide phophodiesterases. The exact mechanism of forskolin's positive inotropic effect is unknown but may be related to a cAMP-dependent increase in Na⁺ permeability, which results in indirect augmentation of Ca²⁺ release. Inhibits MAP kinase in rat renal mesangial cells (IC₅₀ = 25 µM). Also acts as a Hh pathway antagonist. Shown to inhibit apoptosis in cerebellar granule cells and to induce apoptosis in resting human B-lymphocytes.
Form	White to off-white crystalline solid
CAS number	66575-29-9
RTECS	QL6150000
Chemical formula	C₂₂H₃₄O₇
Structure formula
Purity	≥99% by HPLC
Solubility	DMSO (5 mg/ml). Ethanol is reported to inhibit forskolin-mediated activation of adenylate cyclase. DMSO is the recommended solvent; at ≤5% DMSO final concentration, little inhibition of the adenylate cyclase activation will occur.
Storage	+15°C to +30°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, store in the refrigerator (4°C). DMSO stock solutions are stable for up to 4 months at 4°C.
Toxicity	Harmful
Merck USA index	14, 2476
References	D'Orazio, J.A., et al. 2006. Nature 443, 340. Noveen, A., et al. 1996. Biochem. Biophys. Res. Commun. 219, 180. Galli, C., et al. 1995. J. Neurosci. 15, 1172. Li, X., et al. 1995. Am. J. Physiol. 269, C986. Lomo, J., et al. 1995. J. Immunol. 154, 1634. Uneyama, H., et al. 1993. J. Biol. Chem. 268, 168. Laurenza, A., et al. 1989. Trends Pharmacol. Sci. 10, 442. Adashi, E.Y., and Resnick, C.E. 1986. J. Cell. Biochem. 31, 217. Seamon, K.B., and Daly, J.W. 1986. Adv. Cyclic Nucleotide Protein Phosphorylation Res. 20, 1. Huang, R., et al. 1982. Cyclic Nucleotide Res. 8, 385. Metzger, H., and Lindner, E. 1981. IRCS Med. Sci. Biochem. Cardiovasc. System Pharmacol. 9, 99.
Citation	Ryan W Carlin, et al. (2006) PVD9902, a porcine vas deferens epithelial cell line that exhibits neurotransmitter-stimulated anion secretion and expresses numerous HCO3- transporters. American Journal of Physiology Cell Physiology 290, C1560-C1571. Iwona Bogacka, et al. (2005) Structural and functional consequences of mitochondrial biogenesis in human adipocytes in vitro. Journal of Clinical Endocrinology and Metabolism in press,. Michael J. Cross, et al. (2002) The Shb Adaptor Protein Binds to Tyrosine 766 in the FGFR-1 and Regulates the Ras/MEK/MAPK Pathway via FRS2 Phosphorylation in Endothelial Cells. Molecular Biology of the Cell 13, 2881-2893.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Activators > Adenylate and Guanylate Cyclase Activators

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