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			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

344216 Sigma-AldrichFormyl Peptide Receptor-Like 1 Agonist, WKYMVm - Calbiochem

The Formyl Peptide Receptor-Like 1 Agonist, WKYMVm controls the biological activity of Formyl Peptide Receptor-Like 1. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: H₂N-WKYMV-D-M-CONH₂, FPRL1 Agonist, WKYMVm

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概述

Replacement Information

价格及供货情况

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Description
Overview	A potent chemoattractant that enhances leukocyte activity via activation of Formyl Peptide Receptor-Like 1 (FPRL1). Shown to activate phospholipase C-mediated inositol phosphate formation in human U266 myeloma cells (EC₅₀ = 510 pM). Also shown to stimulate inositol phosphate formation in U937 and HL60 cells, but has no effect on a variety of other cell lines (e.g. NIH3T3, PC12, Daudi, Sp2, Jurkat, H9, Molt-4, SupT-1, K562, and RBL-2H3). Stimulates phagocyte chemotaxis and [Ca²⁺] flux, and is more effective than fMLP (Cat. No. 05-22-2500) in generating superoxide in human neutrophils. Radioiodinatable at the tyrosine residue.
Catalogue Number	344216
Brand Family	Calbiochem®
Synonyms	H₂N-WKYMV-D-M-CONH₂, FPRL1 Agonist, WKYMVm

References
References	Bae, Y.S., et al. 2004. J. Immunol. 173, 607. Bae, Y.S., et al. 2003. Mol. Pharmacol. 64, 841. Le, Y., et al. 1999. J. Immunol. 163, 6777. Seo, J.K., et al. 1997. J. Immunol. 158, 1895. Baek, S.H., et al. 1996. J. Biol. Chem. 271, 8170.

Product Information
ATP Competitive	N
Form	Lyophilized
Formulation	Supplied as a trifluoroacetate salt.
Hill Formula	C₄₁H₆₁N₉O₇S₂
Chemical formula	C₄₁H₆₁N₉O₇S₂
Hygroscopic	Hygroscopic
Reversible	N
Quality Level	MQ100

Applications

Biological Information
Primary Target	Formyl Peptide Receptor-Like 1
Primary Target IC<sub>50</sub>	EC50 = 510 pM in activating phospholipase C-mediated inositol phosphate formation in human U266 myeloma cells
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	N
Peptide Sequence	H-Trp-Lys-Tyr-Met-Val-D-Met-CONH₂

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped with Blue Ice or with Dry Ice
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
344216-5MGCN	04055977215328

Documentation

Formyl Peptide Receptor-Like 1 Agonist, WKYMVm - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Formyl Peptide Receptor-Like 1 Agonist, WKYMVm - Calbiochem 分析证书

标题	批号
344216	输入批号

参考

参考信息概述
Bae, Y.S., et al. 2004. J. Immunol. 173, 607. Bae, Y.S., et al. 2003. Mol. Pharmacol. 64, 841. Le, Y., et al. 1999. J. Immunol. 163, 6777. Seo, J.K., et al. 1997. J. Immunol. 158, 1895. Baek, S.H., et al. 1996. J. Biol. Chem. 271, 8170.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	26-June-2008 RFH
Synonyms	H₂N-WKYMV-D-M-CONH₂, FPRL1 Agonist, WKYMVm
Description	A potent chemoattractant that enhances leukocyte activity via activation of Formyl Peptide Receptor-Like 1 (FPRL1). More poteut than fmlp at inducing neutrophil chemotaxis, neutrophil complement receptor 3. Shown to activate phospholipase C-mediated inositol phosphate formation in human U266 myeloma cells (EC₅₀ = 510 pM) and in U937 and HL60 cells. Has no effect inositide phosphate synthecs in a variety of other cell lines (e.g. NIH3T3, PC12, Daudi, Sp2, Jurkat, H9, Molt-4, SupT-1, K562, and RBL-2H3). Radioiodinatable at the tyrosine residue.
Form	Lyophilized
Formulation	Supplied as a trifluoroacetate salt.
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₄₁H₆₁N₉O₇S₂
Peptide Sequence	H-Trp-Lys-Tyr-Met-Val-D-Met-CONH₂
Purity	≥95% by HPLC
Solubility	DMSO (10 mg/ml)
Storage	Protect from light -20°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Bae, Y.S., et al. 2004. J. Immunol. 173, 607. Bae, Y.S., et al. 2003. Mol. Pharmacol. 64, 841. Le, Y., et al. 1999. J. Immunol. 163, 6777. Seo, J.K., et al. 1997. J. Immunol. 158, 1895. Baek, S.H., et al. 1996. J. Biol. Chem. 271, 8170.

种类

Life Science Research > Proteins and Enzymes > Other Proteins

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