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343290 Sigma-AldrichFluoxetine, Hydrochloride - CAS 56296-78-7 - Calbiochem

A cell-permeable phenylpropylamine derived anti-depressant that acts as a selective serotonin re-uptake inhibitor (SSRI).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: dl-N-Methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine, HCl, (±)-N-Methyl-3-phenyl-3-[(α,α,α-trifluoro-p-tolyl)oxy]propylamine, HCl, LY-110140, Prozac

Primary Target: Selective serotonin re-uptake inhibitor

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
56296-78-7	C₁₇H₁₈F₃NO • HCL

价格及供货情况

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Description
Overview	A cell-permeable phenylpropylamine derived anti-depressant that acts as a selective serotonin re-uptake inhibitor (SSRI). Reported to modulate the proliferation of T-cells by increasing the Ca²⁺ influx and thereby influencing the activities of protein kinase A (PKA) and protein kinase C (PKC). Also shown to regulate the phosphorylation of DARPP-32 (dopamine-and cAMP-regulated phosphoprotein of M_r 32,000) and AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors. Shown to trigger oxidative stress-induced apoptotic cell death. Also reported to initiate signaling pathways in neuronal cells leading to activation of ERK and NF-κB.
Catalogue Number	343290
Brand Family	Calbiochem®
Synonyms	dl-N-Methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine, HCl, (±)-N-Methyl-3-phenyl-3-[(α,α,α-trifluoro-p-tolyl)oxy]propylamine, HCl, LY-110140, Prozac

References
References	Bartholoma, P., et al. 2002. Biochem. Pharmacol. 63, 1507. Bian, J.T., et al. 2002. Eur. J. Pharmacol. 453, 159. Zhang, A., et al. 2002. J. Med. Chem. 45, 1930. Svenningsson, P., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 3182. Edgar, V.A., et al. 1999. Eur. J. Pharmacol. 372, 65.

Product Information
CAS number	56296-78-7
ATP Competitive	N
Form	Solid
Hill Formula	C₁₇H₁₈F₃NO • HCL
Chemical formula	C₁₇H₁₈F₃NO • HCL
Hygroscopic	Hygroscopic
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Selective serotonin re-uptake inhibitor
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Harmful
Storage	+2°C to +8°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
343290-25MGCN	04055977195101

Documentation

Fluoxetine, Hydrochloride - CAS 56296-78-7 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Fluoxetine, Hydrochloride - CAS 56296-78-7 - Calbiochem 分析证书

标题	批号
343290	输入批号

参考

参考信息概述
Bartholoma, P., et al. 2002. Biochem. Pharmacol. 63, 1507. Bian, J.T., et al. 2002. Eur. J. Pharmacol. 453, 159. Zhang, A., et al. 2002. J. Med. Chem. 45, 1930. Svenningsson, P., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 3182. Edgar, V.A., et al. 1999. Eur. J. Pharmacol. 372, 65.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	05-July-2017 JSW
Synonyms	dl-N-Methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine, HCl, (±)-N-Methyl-3-phenyl-3-[(α,α,α-trifluoro-p-tolyl)oxy]propylamine, HCl, LY-110140, Prozac
Description	A cell-permeable phenylpropylamine derived anti-depressant that acts as a selective serotonin re-uptake inhibitor (SSRI). Reported to modulate the proliferation of T cells by increasing the Ca²⁺ influx thereby influencing the activities of protein kinase A (PKA) and protein kinase C (PKC). Inhibits leak K⁺ currents in a reversible and voltage-independent manner (IC₅₀ = 780 nM). Also shown to regulate the phosphorylation of DARPP-32 (dopamine-and cAMP-regulated phosphoprotein of Mr 32,000) and AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors. Triggers oxidative stress-induced apoptotic cell death and initiates signaling pathways in neuronal cells leading to an activation of ERK and NF-κB.
Form	Solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	56296-78-7
Chemical formula	C₁₇H₁₈F₃NO • HCL
Structure formula
Purity	≥98% by HPLC
Solubility	H₂O (5 mg/ml) or Methanol (100 mg/ml)
Storage	Protect from light +2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Harmful
Merck USA index	14, 4185
References	Bartholoma, P., et al. 2002. Biochem. Pharmacol. 63, 1507. Bian, J.T., et al. 2002. Eur. J. Pharmacol. 453, 159. Zhang, A., et al. 2002. J. Med. Chem. 45, 1930. Svenningsson, P., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 3182. Edgar, V.A., et al. 1999. Eur. J. Pharmacol. 372, 65.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Calcium Signaling > Other Calcium Channel Modulators

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