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343020 Sigma-AldrichFlt-3 Inhibitor - CAS 301305-73-7 - Calbiochem

The Flt-3 Inhibitor, also referenced under CAS 301305-73-7, controls the biological activity of Flt-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

Primary Target: Flt-3

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
301305-73-7	C₁₈H₂₀N₂O₄S

价格及供货情况

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Description
Overview	A cell-permeable thienylcarboxamide compound that acts as a potent, ATP-competitive, and highly selective Flt-3 inhibitor (IC₅₀ = 42 nM) with little effect against a panel of 22 other kinases (IC₅₀ ≥3 µM). Shown to exhibit antiproliferative properties against the human acute myelogenous leukemia cell line MV4-11 (IC₅₀ = 340 nM) expressing constitutively active Flt-3.
Catalogue Number	343020
Brand Family	Calbiochem®

References
References	Patch, R.J., et al. 2006. Bioorg. Med. Chem. Lett. 16, 3282.

Product Information
CAS number	301305-73-7
ATP Competitive	Y
Form	White solid
Hill Formula	C₁₈H₂₀N₂O₄S
Chemical formula	C₁₈H₂₀N₂O₄S
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Flt-3
Primary Target IC<sub>50</sub>	42 nM against Flt-3
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Irritant
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
343020-5MGCN	04055977195019

Documentation

Flt-3 Inhibitor - CAS 301305-73-7 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Flt-3 Inhibitor - CAS 301305-73-7 - Calbiochem 分析证书

标题	批号
343020	输入批号

参考

参考信息概述
Patch, R.J., et al. 2006. Bioorg. Med. Chem. Lett. 16, 3282.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	10-October-2007 JSW
Description	A cell-permeable thienylcarboxamide compound that acts as a potent, ATP-competitive, and highly selective Flt-3 inhibitor (IC₅₀ = 42 nM) with little effect against a panel of 22 other kinases (IC₅₀ ≥3 µM). Shown to exhibit antiproliferative properties against the human acute myelogenous leukemia cell line MV4-11 (IC₅₀ = 340 nM) expressing constitutively active Flt-3.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	301305-73-7
Chemical formula	C₁₈H₂₀N₂O₄S
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (<4 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Irritant
References	Patch, R.J., et al. 2006. Bioorg. Med. Chem. Lett. 16, 3282.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Tyrosine Kinase (PTK) Inhibitors

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