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A cell-permeable aminopropanediol immunosuppressive agent that displays lymphocyte sequestration properties. Reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPγS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).
Brinkmann, V and Lynch, K. R., 2002. Curr. Opin. Immunol.14, 569. Brinkmann, V., et al. 2002. J. Biol. Chem.277, 21453. Mandala, S., et al. 2002. Science296, 346. Chiba, K., et al. 1998. J. Immunol.160, 5037. Adachi, K., et al. 1995. Bioorg. Med. Chem. Lett.5, 583.
Product Information
CAS number
162359-56-0
Form
Solid
Hill Formula
C₁₉H₃₃NO₂ • HCl
Chemical formula
C₁₉H₃₃NO₂ • HCl
Hygroscopic
Hygroscopic
Structure formula Image
Applications
Biological Information
Purity
≥98% by TLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code
Shipped with Blue Ice or with Dry Ice
Toxicity
Standard Handling
Storage
-20°C
Protect from Light
Protect from light
Hygroscopic
Hygroscopic
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas
Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号
GTIN
344597-10MGCN
04055977214796
Documentation
FTY720 分析证书
标题
批号
344597
参考
参考信息概述
Brinkmann, V and Lynch, K. R., 2002. Curr. Opin. Immunol.14, 569. Brinkmann, V., et al. 2002. J. Biol. Chem.277, 21453. Mandala, S., et al. 2002. Science296, 346. Chiba, K., et al. 1998. J. Immunol.160, 5037. Adachi, K., et al. 1995. Bioorg. Med. Chem. Lett.5, 583.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
A cell-permeable aminopropanediol immunosuppressive agent that displays lymphocyte sequestration properties. Reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPγS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).
Form
Solid
Intert gas (Yes/No)
Packaged under inert gas
CAS number
162359-56-0
Chemical formula
C₁₉H₃₃NO₂ • HCl
Structure formula
Purity
≥98% by TLC
Solubility
DMSO (20 mg/ml) or Ethanol (20 mg/ml)
Storage
Protect from light
-20°C
Hygroscopic
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
Brinkmann, V and Lynch, K. R., 2002. Curr. Opin. Immunol.14, 569. Brinkmann, V., et al. 2002. J. Biol. Chem.277, 21453. Mandala, S., et al. 2002. Science296, 346. Chiba, K., et al. 1998. J. Immunol.160, 5037. Adachi, K., et al. 1995. Bioorg. Med. Chem. Lett.5, 583.
