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Immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca2+ release. Inhibits the Ca2+-dependent phosphatase, Protein Phosphatase 2B (Calcineurin; Cat. No. 539568), as well as Na+,K+-ATPase in nephron segments. Also shown to inhibit aldosterone-induced synthesis of Giα-3 protein.
Catalogue Number
342500
Brand Family
Calbiochem®
Synonyms
Tacrolimus
References
References
Asano, K., et al. 1996. In Vivo 10, 537. McCall, E., et al. 1996. Circ. Res. 79, 1110. Raufman, J.P., et al. 1996. J. Biol. Chem. 271, 19877. Rokaw, M.D., et al. 1996. Am. J. Physiol. 271, C194.
Immunosuppressant that blocks T cell proliferation
Purity
≥98% by TLC
Physicochemical Information
Cell permeable
N
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECS
KD4200000
Safety Information
R Phrase
R: 25
Toxic if swallowed.
S Phrase
S: 36/37/39-45
Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Toxic
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
+2°C to +8°C
Protect from Moisture
Protect from moisture
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号
GTIN
342500-5MGCN
04055977195002
Documentation
FK-506, Streptomyces sp. - CAS 104987-11-3 - Calbiochem MSDS
FK-506, Streptomyces sp. - CAS 104987-11-3 - Calbiochem 分析证书
标题
批号
342500
参考
参考信息概述
Asano, K., et al. 1996. In Vivo 10, 537. McCall, E., et al. 1996. Circ. Res. 79, 1110. Raufman, J.P., et al. 1996. J. Biol. Chem. 271, 19877. Rokaw, M.D., et al. 1996. Am. J. Physiol. 271, C194.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
27-April-2009 JSW
Synonyms
Tacrolimus
Description
Immunosuppressant that blocks T-cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 Binding Protein, thereby reversing its effects on sarcoplamic reticulum Ca2+ release. Shown to inhibit the Ca2+-dependent phosphatase, Calcineurin (Cat. No. 539565), as well as Na+-K+-ATPase in nephron segments. Also shown to inhibit aldosterone-induced synthesis of Giα-3 protein.
Form
Off-white solid
CAS number
104987-11-3
RTECS
KD4200000
Structure formula
Purity
≥98% by TLC
Solubility
DMSO (10 mg/ml) or Methanol (5 mg/ml)
Storage
Protect from moisture
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Toxic
References
Asano, K., et al. 1996. In Vivo 10, 537. McCall, E., et al. 1996. Circ. Res. 79, 1110. Raufman, J.P., et al. 1996. J. Biol. Chem. 271, 19877. Rokaw, M.D., et al. 1996. Am. J. Physiol. 271, C194.
