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341608 Sigma-AldrichFGF Receptor Tyrosine Kinase Inhibitor - CAS 192705-79-6 - Calbiochem

The FGF Receptor Tyrosine Kinase Inhibitor, also referenced under CAS 192705-79-6, controls the biological activity of FGF Receptor Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: PD 166866, 1-(2-Amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butyl urea

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
192705-79-6	C₂₀H₂₄N₆O₃

价格及供货情况

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Description
Overview	A cell-permeable pyridopyrimidinyl urea compound that acts a potent, ATP-competitive inhibitor of FGFR (IC₅₀ = 60 nM using FGFR1) with excellent selectivity over PDGFRβ, EGFR, insulin receptor, and c-Src (IC₅₀ > 50 µM).
Catalogue Number	341608
Brand Family	Calbiochem®
Synonyms	PD 166866, 1-(2-Amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butyl urea

References
References	Panek, R.L., et al. 1998. J. Pharm. Exp. Ther. 286, 569. Hamby, J.M., et al. 1997. J. Med. Chem. 40, 2296.

Product Information
CAS number	192705-79-6
Form	Off-white solid
Hill Formula	C₂₀H₂₄N₆O₃
Chemical formula	C₂₀H₂₄N₆O₃
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥97% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/37/38 Irritating to eyes, respiratory system and skin.
S Phrase	S: 26-36-45 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Irritant
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
341608-5MGCN	04055977195217

Documentation

FGF Receptor Tyrosine Kinase Inhibitor - CAS 192705-79-6 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

FGF Receptor Tyrosine Kinase Inhibitor - CAS 192705-79-6 - Calbiochem 分析证书

标题	批号
341608	输入批号

参考

参考信息概述
Panek, R.L., et al. 1998. J. Pharm. Exp. Ther. 286, 569. Hamby, J.M., et al. 1997. J. Med. Chem. 40, 2296.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	08-April-2011 RFH
Synonyms	PD 166866, 1-(2-Amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butyl urea
Description	A cell-permeable pyridopyrimidinyl urea compound that acts a potent, ATP-competitive inhibitor of FGFR (IC₅₀ = 60 nM using FGFR1) with excellent selectivity over PDGFRβ, EGFR, insulin receptor, and c-Src (IC₅₀ > 50 µM).
Form	Off-white solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	192705-79-6
Chemical formula	C₂₀H₂₄N₆O₃
Structure formula
Purity	≥97% by HPLC
Solubility	DMSO (10 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Irritant
References	Panek, R.L., et al. 1998. J. Pharm. Exp. Ther. 286, 569. Hamby, J.M., et al. 1997. J. Med. Chem. 40, 2296.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Tyrosine Kinase (PTK) Inhibitors

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