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341220 Sigma-AldrichExo1 - CAS 75541-83-2 - Calbiochem

A cell-permeable methylanthranilate analog that reversibly inhibits vesicular traffic from ER to Golgi in mammalian cells by inducing tubulation and collapsing of the Golgi membrane.

Exo1 - CAS 75541-83-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 2-(4-Fluorobenzoylamino)methylbenzoate, 2-(4-Fluorobenzoylamino)benzoic Acid Methyl Ester, ER Export Inhibitor I

Primary Target: Golgi ARF1 GTPase

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
75541-83-2	C₁₅H₁₂FNO₃

价格及供货情况

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Description
Overview	A cell-permeable methylanthranilate analog that reversibly inhibits vesicular traffic from ER to Golgi in mammalian cells (IC₅₀ = 20 µM in BSC1 cells) by inducing tubulation and collapsing of the Golgi membrane and redirecting the traffic back to ER. Acts as a potent and selective modifier of Golgi ARF1 GTPase activity. Unlike another membrane traffic inhibitor Brefeldin A (BFA; Cat. No. 203729), its effect seems to be limited to Golgi, as no effect can be detected on endocytic organelles, such as endosomes and TGN (trans-Golgi network). Its inhibitory mechanism and target(s) appear to be quite different from those of BFA and thus serves as a valuable alternative that complements BFA in membrane traffic studies.
Catalogue Number	341220
Brand Family	Calbiochem®
Synonyms	2-(4-Fluorobenzoylamino)methylbenzoate, 2-(4-Fluorobenzoylamino)benzoic Acid Methyl Ester, ER Export Inhibitor I

References
References	Feng. Y., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 6469.

Product Information
CAS number	75541-83-2
ATP Competitive	N
Form	White solid
Hill Formula	C₁₅H₁₂FNO₃
Chemical formula	C₁₅H₁₂FNO₃
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Golgi ARF1 GTPase
Primary Target IC<sub>50</sub>	20 µM inhibiting vesicular traffic from ER to Golgi in BSC1 cells
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Harmful
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
341220-25MGCN	04055977215496

Documentation

Exo1 - CAS 75541-83-2 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Exo1 - CAS 75541-83-2 - Calbiochem 分析证书

标题	批号
341220	输入批号

参考

参考信息概述
Feng. Y., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 6469.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	07-April-2008 RFH
Synonyms	2-(4-Fluorobenzoylamino)methylbenzoate, 2-(4-Fluorobenzoylamino)benzoic Acid Methyl Ester, ER Export Inhibitor I
Description	A cell-permeable methylanthranilate analog that reversibly blocks vesicular traffic from the ER to the Golgi in mammalian cells (IC₅₀ = 20 µM in BSC1 cells) by inducing tubulation and collapsing of the Golgi membrane and re-directing the traffic back to the ER. Acts as a potent and selective modifier of Golgi ARF1 GTPase activity. Unlike another membrane traffic inhibitor, Brefeldin A (BFA) (Cat. No. 203729), the effects appear to be limited to the Golgi, as no effects are detected on endocytic organelles, such as endosomes and trans-Golgi network (TGN). The inhibitory mechanism and target(s) appear to be different from those of BFA, thus making it a valuable alternative that complements BFA in membrane trafficking studies.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	75541-83-2
Chemical formula	C₁₅H₁₂FNO₃
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (25 mg/ml), DMF (25 mg/ml), Methanol (5 mg/ml), or Ethanol (5 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Harmful
References	Feng. Y., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 6469.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Extracellular Matrix, Adhesion and Cytoskeletal Research Tools

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