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324732 ErbB2 Inhibitor II - CAS 928207-02-7 - Calbiochem

The ErbB2 Inhibitor II, also referenced under CAS 928207-02-7, controls the biological activity of ErbB2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: 4-(3-Phenoxyphenyl)-5-cyano-2H-1,2,3-triazole

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324732
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
928207-02-7C₁₅H₁₀N₄O

价格及供货情况

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324732-5MGCN
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      		 塑胶安瓿;塑胶针药瓶 5 mg
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      Description
      OverviewA cell-permeable triazole compound that targets the ATP-binding site of erbB2/HER2 and reduces the phosphorylation of erbB2 in MDA-MB-453 cells (IC50 = 6.6 µM), but not that of the overexpressed erbB1 in MDA-MB-468 cells even at concentrations as high as 100 µM. Shown to suppress MDA-MB-453 growth with an IC50 of 30.9 µM.
      Catalogue Number324732
      Brand Family Calbiochem®
      Synonyms4-(3-Phenoxyphenyl)-5-cyano-2H-1,2,3-triazole
      References
      ReferencesCheng, Z. Y., et al. 2007. Bioorg. Med. Chem. 15, 1533.
      Product Information
      CAS number928207-02-7
      FormYellow solid
      Hill FormulaC₁₅H₁₀N₄O
      Chemical formulaC₁₅H₁₀N₄O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      产品目录编号 GTIN
      324732-5MGCN 04055977216028

      Documentation

      ErbB2 Inhibitor II - CAS 928207-02-7 - Calbiochem MSDS

      职位

      物料安全数据表 (MSDS) 

      ErbB2 Inhibitor II - CAS 928207-02-7 - Calbiochem 分析证书

      标题批号
      324732

      参考

      参考信息概述
      Cheng, Z. Y., et al. 2007. Bioorg. Med. Chem. 15, 1533.
      数据表

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-April-2011 RFH
      Synonyms4-(3-Phenoxyphenyl)-5-cyano-2H-1,2,3-triazole
      DescriptionA cell-permeable triazole compound that targets the ATP-binding site of erbB2/HER2 and reduces the phosphorylation of erbB2 in MDA-MB-453 cells (IC50 = 6.6 µM), but not that of the overexpressed erbB1 in MDA-MB-468 cells even at concentrations as high as 100 µM. Shown to suppress MDA-MB-453 growth with an IC50 of 30.9 µM.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number928207-02-7
      Chemical formulaC₁₅H₁₀N₄O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesCheng, Z. Y., et al. 2007. Bioorg. Med. Chem. 15, 1533.