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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

324693 Sigma-AldrichEmetine, Dihydrochloride - CAS 316-42-7 - Calbiochem

Principal alkaloid of ipecac, isolated from the ground roots of Uragoga ipecacuanha.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 6ʹ,7ʹ,10,11-Tetramethoxyemetan, 2HCl

Primary Target: Movement of ribosomes along the mRNA

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
316-42-7	C₂₉H₄₀N₂O₄ · 2HCl

价格及供货情况

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Description
Overview	Principal alkaloid of ipecac, isolated from the ground roots of Uragoga ipecacuanha. Irreversibly blocks protein synthesis in eukaryotes by inhibiting the movement of ribosomes along the mRNA. Induces hypotension by blocking adrenoreceptors. Interferes with cytometric analysis of DNA replication at the early S phase. Also identified as a specific inhibitor of HIF-2α protein stability and transcriptional activity (IC₅₀ ≤1 µM.
Catalogue Number	324693
Brand Family	Calbiochem®
Synonyms	6ʹ,7ʹ,10,11-Tetramethoxyemetan, 2HCl

References
References	Kong, H.S., et al. 2010. Mol. Pharmacol. in press. Khan, M.A. 1995. Prog. Neurobiol. 46, 541. Kokuho, T., et al. 1995. Immunobiology 193, 42. Lee, Y.S., and Wurster, R.D. 1995. Cancer Lett. 93, 157. Burhans, W.C., et al. 1991. EMBO J. 10, 4351. Filley, E.A., and Rook, G.A. 1991. Infect. Immun. 59, 2567. Landis, R.C., et al. 1991. J. Immunol. 146, 128. Schweighoffer, T., et al. 1991. Histochemistry 96, 93.

References

Kong, H.S., et al. 2010. Mol. Pharmacol. in press.
Khan, M.A. 1995. Prog. Neurobiol. 46, 541.
Kokuho, T., et al. 1995. Immunobiology 193, 42.
Lee, Y.S., and Wurster, R.D. 1995. Cancer Lett. 93, 157.
Burhans, W.C., et al. 1991. EMBO J. 10, 4351.
Filley, E.A., and Rook, G.A. 1991. Infect. Immun. 59, 2567.
Landis, R.C., et al. 1991. J. Immunol. 146, 128.
Schweighoffer, T., et al. 1991. Histochemistry 96, 93.

Product Information
CAS number	316-42-7
ATP Competitive	N
Form	White to off-white solid
Hill Formula	C₂₉H₄₀N₂O₄ · 2HCl
Chemical formula	C₂₉H₄₀N₂O₄ · 2HCl
Hygroscopic	Hygroscopic
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Movement of ribosomes along the mRNA
Primary Target IC<sub>50</sub>	≤1 µM as a specific inhibitor of HIF-2α protein stability and transcriptional activity
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	JY5250000

Safety Information
R Phrase	R: 28-36/38 Very toxic if swallowed. Irritating to eyes and skin.
S Phrase	S: 28-36/37-45 Wear suitable protective clothing and gloves. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Highly Toxic
Hazardous Materials Attention:	Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage	+2°C to +8°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
324693-250MGCN	04055977215885

Documentation

Emetine, Dihydrochloride - CAS 316-42-7 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Emetine, Dihydrochloride - CAS 316-42-7 - Calbiochem 分析证书

标题	批号
324693	输入批号

参考

参考信息概述
Kong, H.S., et al. 2010. Mol. Pharmacol. in press. Khan, M.A. 1995. Prog. Neurobiol. 46, 541. Kokuho, T., et al. 1995. Immunobiology 193, 42. Lee, Y.S., and Wurster, R.D. 1995. Cancer Lett. 93, 157. Burhans, W.C., et al. 1991. EMBO J. 10, 4351. Filley, E.A., and Rook, G.A. 1991. Infect. Immun. 59, 2567. Landis, R.C., et al. 1991. J. Immunol. 146, 128. Schweighoffer, T., et al. 1991. Histochemistry 96, 93.

参考信息概述

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	15-April-2019 JSW
Synonyms	6ʹ,7ʹ,10,11-Tetramethoxyemetan, 2HCl
Description	Principle alkaloid of ipecac, isolated from the ground roots of Uragoga ipecacuanha. Irreversibly blocks protein synthesis in eukaryotes by inhibiting the movement of ribosomes along the mRNA. Induces hypotension by blocking adrenoreceptors. Inhibits cytometric analysis of DNA replication at the early S phase. Also identified as a specific inhibitor of HIF-2α protein stability and transcriptional activity (IC₅₀ ≤1 µM.
Form	White to off-white solid
CAS number	316-42-7
RTECS	JY5250000
Chemical formula	C₂₉H₄₀N₂O₄ · 2HCl
Structure formula
Purity	≥98% by HPLC
Solubility	Ethanol or H₂O (20 mg/ml)
Storage	Protect from light +2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Highly Toxic
Merck USA index	14, 3559
References	Kong, H.S., et al. 2010. Mol. Pharmacol. in press. Khan, M.A. 1995. Prog. Neurobiol. 46, 541. Kokuho, T., et al. 1995. Immunobiology 193, 42. Lee, Y.S., and Wurster, R.D. 1995. Cancer Lett. 93, 157. Burhans, W.C., et al. 1991. EMBO J. 10, 4351. Filley, E.A., and Rook, G.A. 1991. Infect. Immun. 59, 2567. Landis, R.C., et al. 1991. J. Immunol. 146, 128. Schweighoffer, T., et al. 1991. Histochemistry 96, 93.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Protein Synthesis Inhibitors

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