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324688
Sigma-AldrichEllipticine - CAS 519-23-3 - Calbiochem
A cell-permeable antitumor alkaloid that acts as an inhibitor of topoisomerase II and acts as an intercalative agent that stimulates topoisomerase II-mediated DNA breakage.
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Ellipticine - CAS 519-23-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
A cell-permeable antitumor alkaloid that acts as an inhibitor of topoisomerase II and acts as an intercalative agent that stimulates topoisomerase II-mediated DNA breakage. Is also capable of uncoupling mitochondrial oxidative phosphorylation.
Catalogue Number
324688
Brand Family
Calbiochem®
Synonyms
5,11-Dimethyl-6H-pyrido[4,3-b]carbazole
References
References
Froelich-Ammon, S.J., et al. 1995. J. Biol. Chem. 270, 14998. Schwaller, M.A., et al. 1995. J. Biol. Chem.270, 22709. Pommier, Y., et al. 1985. Biochemistry24, 6406.
Toxic by inhalation, in contact with skin and if swallowed. Limited evidence of a carcinogenic effect.
S Phrase
S: 22-36/37/39-45
Do not breathe dust. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
+2°C to +8°C
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Froelich-Ammon, S.J., et al. 1995. J. Biol. Chem. 270, 14998. Schwaller, M.A., et al. 1995. J. Biol. Chem.270, 22709. Pommier, Y., et al. 1985. Biochemistry24, 6406.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
25-January-2013 JSW
Synonyms
5,11-Dimethyl-6H-pyrido[4,3-b]carbazole
Description
A topoisomerase II inhibitor. Acts as an intercalative alkaloid that stimulates topoisomerase II-mediated DNA breakage. Is also capable of uncoupling mitochondrial oxidative phosphorylation.
Form
Bright yellow solid
CAS number
519-23-3
RTECS
UU8825000
Chemical formula
C₁₇H₁₄N₂
Structure formula
Purity
≥99% by HPLC
Solubility
DMSO (5 mg/ml) or Ethanol (1 mg/ml)
Storage
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Toxic & Carcinogenic / Teratogenic
Merck USA index
14, 3548
References
Froelich-Ammon, S.J., et al. 1995. J. Biol. Chem. 270, 14998. Schwaller, M.A., et al. 1995. J. Biol. Chem.270, 22709. Pommier, Y., et al. 1985. Biochemistry24, 6406.
