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A cell-permeable, reversible, potent antioxidant that has anti-mutagenic and anti-carcinogenic properties. Acts as a selective and ATP-competitive inhibitor of CK2 (IC50 = 40 nM). Moderately inhibits DNA topoisomerases I and II, Lyn, PKA catalytic subunit, Lyk, GSK-3, PKC, and FGR (IC50 = 1.8, 2.1, 2.9, 3.5, 4.3, 7.5, 8.0, and 9.4 µM, respectively). Only minimally inhibits DYRK1a, CSK, RET, Flt3, and NPM-ALK (IC50 >40 µM). Shown to act as an uncompetitive inhibitor of arginine methyltransferase CARM1 and block histone H3R17 methylation.
Catalogue Number
324683
Brand Family
Calbiochem®
Synonyms
4,4ʹ,5,5ʹ,6,6ʹ-Hexahydroxydiphenic Acid 2,6,2ʹ,6ʹ-Dilactone, TBBD, PRMT Inhibitor II
References
References
Selvi, B.R., et al. 2009, J. Biol. Chem. In press. Cozza, G., et al. 2006. J. Med. Chem.49, 2363. Wang, B.H., et al. 1998. Planta Med. 64, 195. Constantinou, A., et al. 1995. Nutr. Cancer23, 121. Hickey, M.J., et al. 1995. Biochem. Soc. Trans.23, 607s.
40 nM against CK2; 1.8, 2.1, 2.9, 3.5, 4.3, 7.5, 8.0, and 9.4 µM, against DNA topoisomerases I and II, Lyn, PKA catalytic subunit, Lyk, GSK-3, PKC, and FGR, respectively
Purity
≥98% by HPLC
Physicochemical Information
Cell permeable
Y
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECS
DJ2620000
Safety Information
R Phrase
R: 36/37/38
Irritating to eyes, respiratory system and skin.
S Phrase
S: 26-36
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Irritant
Storage
+15°C to +30°C
Protect from Light
Protect from light
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 1 week at -20°C. Alkaline solutions are unstable and should be prepared just prior to use.
Packaging Information
Packaged under inert gas
Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号
GTIN
324683-500MGCN
04055977196856
Documentation
Ellagic Acid, Dihydrate - CAS 476-66-4 - Calbiochem MSDS
Ellagic Acid, Dihydrate - CAS 476-66-4 - Calbiochem 分析证书
标题
批号
324683
参考
参考信息概述
Selvi, B.R., et al. 2009, J. Biol. Chem. In press. Cozza, G., et al. 2006. J. Med. Chem.49, 2363. Wang, B.H., et al. 1998. Planta Med. 64, 195. Constantinou, A., et al. 1995. Nutr. Cancer23, 121. Hickey, M.J., et al. 1995. Biochem. Soc. Trans.23, 607s.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
06-February-2019 JSW
Synonyms
4,4ʹ,5,5ʹ,6,6ʹ-Hexahydroxydiphenic Acid 2,6,2ʹ,6ʹ-Dilactone, TBBD, PRMT Inhibitor II
Description
A cell-permeable, reversible, and potent antioxidant that has anti-mutagenic and anti-carcinogenic properties. Acts as a selective and ATP-competitive inhibitor of CK2 (IC50 = 40 nM). Moderately inhibits DNA topoisomerases I and II, Lyn, PKA catalytic subunit, Lyk, GSK-3, PKC, and FGR (IC50 = 1.8, 2.1, 2.9, 3.5, 4.3, 7.5, 8.0, and 9.4 µM, respectively). Only minimally inhibits DYRK1a, CSK, RET, Flt3, and NPM-ALK (IC50 >40 µM). Shown to act as an uncompetitive inhibitor of arginine methyltransferase CARM1 and block histone H3R17 methylation.
Form
Slightly Beige Powder
Intert gas (Yes/No)
Packaged under inert gas
CAS number
476-66-4
RTECS
DJ2620000
Chemical formula
C₁₄H₆O₈ · 2H₂O
Structure formula
Purity
≥98% by HPLC
Solubility
1 M NaOH (10 mg/ml) or Ethanol (10 mg/ml). For complete solubilization in ethanol, slight heating may be required.
Storage
Protect from light
+15°C to +30°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 1 week at -20°C. Alkaline solutions are unstable and should be prepared just prior to use.
Toxicity
Irritant
Merck USA index
14, 3547
References
Selvi, B.R., et al. 2009, J. Biol. Chem. In press. Cozza, G., et al. 2006. J. Med. Chem.49, 2363. Wang, B.H., et al. 1998. Planta Med. 64, 195. Constantinou, A., et al. 1995. Nutr. Cancer23, 121. Hickey, M.J., et al. 1995. Biochem. Soc. Trans.23, 607s.
