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324759 Sigma-AldrichElastase Inhibitor IV - CAS 127373-66-4 - Calbiochem

The Elastase Inhibitor IV, also referenced under CAS 127373-66-4, controls the biological activity of Elastase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: N-(o-(p-Pivaloyloxybenzene)sulfonylaminobenzoyl)glycine, N-(2-(4-(2,2-Dimethylpropionyloxy)phenylsulfonylamino)benzoyl)aminoacetic acid

Primary Target: Neutrophil elastase

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
127373-66-4	C₂₀H₂₂N₂O₇S

价格及供货情况

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Description
Overview	A cell-permeable sulfanilide compound that acts as a potent, substrate-competitive, and highly specific inhibitor of neutrophil elastase (IC₅₀ = 19-49 nM in rat, rabbit, hamster, human, and mouse leukocyte elastase). Displays >100-fold greater selectivity over pancreas elastase (IC₅₀ = 5.6 µM). Does not inhibit trypsin, thrombin, plasmin, kallikrein, chymotrypsin, and cathepsin G even at concentrations as high as 100 µM. Effectively suppresses human neutrophil elastase-induced lung hemorrhage and skin capillary permeability in vivo. Also reported to inhibit mast cell Stat6-protease.
Catalogue Number	324759
Brand Family	Calbiochem®
Synonyms	N-(o-(p-Pivaloyloxybenzene)sulfonylaminobenzoyl)glycine, N-(2-(4-(2,2-Dimethylpropionyloxy)phenylsulfonylamino)benzoyl)aminoacetic acid

References
References	Suzuki, K., et al. 2003. Biochem. Biophys. Res. Commun. 309, 768. Kawabata, K., et al. 1991. Biochem. Biophys. Res. Commun. 177, 814.

Product Information
CAS number	127373-66-4
ATP Competitive	N
Form	White to off-white solid
Hill Formula	C₂₀H₂₂N₂O₇S
Chemical formula	C₂₀H₂₂N₂O₇S
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Neutrophil elastase
Primary Target IC<sub>50</sub>	19-49 nM in rat, rabbit, hamster, human, and mouse leukocyte elastase
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
324759-1MGCN	04055977216080

Documentation

Elastase Inhibitor IV - CAS 127373-66-4 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Elastase Inhibitor IV - CAS 127373-66-4 - Calbiochem 分析证书

标题	批号
324759	输入批号

参考

参考信息概述
Suzuki, K., et al. 2003. Biochem. Biophys. Res. Commun. 309, 768. Kawabata, K., et al. 1991. Biochem. Biophys. Res. Commun. 177, 814.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	03-April-2008 RFH
Synonyms	N-(o-(p-Pivaloyloxybenzene)sulfonylaminobenzoyl)glycine, N-(2-(4-(2,2-Dimethylpropionyloxy)phenylsulfonylamino)benzoyl)aminoacetic acid
Description	A cell-permeable, potent, substrate-competitive, and highly specific inhibitor of neutrophil elastase (IC₅₀ = 19-49 nM using rat, rabbit, hamster, human, and mouse leukocyte elastase). Displays about 100-fold greater selectivity over pancreatic elastase (IC₅₀ = 5.6 µM) and is inactive against trypsin, thrombin, plasmin, kallikrein, chymotrypsin, and cathepsin G even at concentrations as high as 100 µM. Effectively suppresses human neutrophil elastase-induced lung hemorrhage and skin capillary permeability in vivo. Also reported to inhibit mast cell Stat6-protease.
Form	White to off-white solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	127373-66-4
Chemical formula	C₂₀H₂₂N₂O₇S
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (10 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Suzuki, K., et al. 2003. Biochem. Biophys. Res. Commun. 309, 768. Kawabata, K., et al. 1991. Biochem. Biophys. Res. Commun. 177, 814.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Elastase Inhibitors

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