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341209 Sigma-AldrichEUK-8 - CAS 53177-12-1 - Calbiochem

A synthetic salen-manganese complex with high superoxide dismutase (SOD) and catalase-mimic activities, and oxyradical scavenging activities.

EUK-8 - CAS 53177-12-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
53177-12-1	C₁₆H₁₄ClMnN₂O₂

价格及供货情况

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Description
Overview	A synthetic salen-manganese complex with high superoxide dismutase (SOD) and catalase-mimic activities, and oxyradical scavenging activities. Shown to have protective effects in numerous models for disease processes associated with oxidative stress, including inflammation, cardiovascular diseases, acute critical illness, autoimmune diseases, and neurological disorders. Useful in preventing cardiac damage caused by ischemic reperfusion. Also prevents β-amyloid peptide (Aβ)-induced free radical formation and lipid peroxidation. Imparts protection against Aβ₄₀ and Aβ₄₂ toxicity in hippocampal cultures.
Catalogue Number	341209
Brand Family	Calbiochem®

References
References	Colparet, E. E. and Lefebure, R. A. 2000. Br. J. Pharmacol. 130, 359. Brandier, C., et al. 1997. J. Vasc. Res. 34, 49. Doctrow, S.R., et al. 1997. Adv. Pharmacol. 38, 247. Bruce, A.J., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 2312. Pucheu, S., et al. 1996. Cardiovasc. Drug Ther. 10, 331. Baudry, M., et al. 1993. Biochem. Biophys. Res. Commun. 192, 964.

Product Information
CAS number	53177-12-1
ATP Competitive	N
Declaration	Not available for sale in Africa, Australia, Great Britain, Europe, Latvia, New Zealand, and the United States.
Form	Dark brown solid
Hill Formula	C₁₆H₁₄ClMnN₂O₂
Chemical formula	C₁₆H₁₄ClMnN₂O₂
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Superoxide dismutase (SOD) and catalase-mimic activities, and oxyradical scavenging activities
Purity	≥90% by elemental analysis

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
341209-10MGCN	04055977215465

Documentation

EUK-8 - CAS 53177-12-1 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

EUK-8 - CAS 53177-12-1 - Calbiochem 分析证书

标题	批号
341209	输入批号

参考

参考信息概述
Colparet, E. E. and Lefebure, R. A. 2000. Br. J. Pharmacol. 130, 359. Brandier, C., et al. 1997. J. Vasc. Res. 34, 49. Doctrow, S.R., et al. 1997. Adv. Pharmacol. 38, 247. Bruce, A.J., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 2312. Pucheu, S., et al. 1996. Cardiovasc. Drug Ther. 10, 331. Baudry, M., et al. 1993. Biochem. Biophys. Res. Commun. 192, 964.

小册子

标题
Pathways and Biomarkers of Oxidative Stress

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	24-June-2008 RFH
Description	A synthetic salen-manganese complex with high superoxide dismutase (SOD), catalase, and oxyradical scavenger activities. Shown to have protective effects in numerous models for disease processes associated with oxidative stress, including inflammation, cardiovascular diseases, acute critical illness, autoimmune diseases, and neurological disorders. Useful in preventing cardiac damage caused by ischemic reperfusion. Also prevents β-amyloid peptide (Aβ)-induced free radical formation and lipid peroxidation and imparts protection against Aβ₄₀ and Aβ₄₂ toxicity in hippocampal cultures.
Form	Dark brown solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	53177-12-1
Chemical formula	C₁₆H₁₄ClMnN₂O₂
Structure formula
Purity	≥90% by elemental analysis
Solubility	DMSO (20 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.
Toxicity	Standard Handling
References	Colparet, E. E. and Lefebure, R. A. 2000. Br. J. Pharmacol. 130, 359. Brandier, C., et al. 1997. J. Vasc. Res. 34, 49. Doctrow, S.R., et al. 1997. Adv. Pharmacol. 38, 247. Bruce, A.J., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 2312. Pucheu, S., et al. 1996. Cardiovasc. Drug Ther. 10, 331. Baudry, M., et al. 1993. Biochem. Biophys. Res. Commun. 192, 964.

种类

Life Science Research > Inhibitors and Biochemicals > Biochemicals > Nucleotides, Nucleosides, Purines, Pyrimidines and Nucleic Acids > Antioxidants and Free Radical Scavengers

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