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328006 Sigma-AldrichERK Inhibitor - CAS 1049738-54-6 - Calbiochem

The ERK Inhibitor, also referenced under CAS 1049738-54-6, controls the biological activity of ERK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione, HCl

Primary Target: ERK

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
1049738-54-6	C₁₄H₁₆N₂O₃S • HCl

价格及供货情况

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Description
Overview	A cell-permeable and reversible thiazolidinedione compound that displays anti-proliferative properties (IC₅₀ ≤ 25 µM in HeLa, A549, and SUM-159 tumor cells). Preferentially binds to ERK2 with a K_D of ~5 µM and prevents its interaction with protein substrates. Shown to block ERK-mediated phosphorylation of ribosomal S6 kinase-1 (RSK-1) and ternary complex factor Elk-1 in HeLa cells, while exhibiting little effect on ERK1/2 phosphorylation by MEK1/2.
Catalogue Number	328006
Brand Family	Calbiochem®
Synonyms	3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione, HCl

References
References	Hancock, C. N., et al. 2005. J. Med. Chem. 48, 4586.

Product Information
CAS number	1049738-54-6
ATP Competitive	N
Form	Light yellow solid
Hill Formula	C₁₄H₁₆N₂O₃S • HCl
Chemical formula	C₁₄H₁₆N₂O₃S • HCl
Hygroscopic	Hygroscopic
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	ERK
Primary Target IC<sub>50</sub>	≤ 25 µM for anti-proliferative properties in HeLa, A549, and SUM-159 tumor cells; KD of ~5 µM for ERK2
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
328006-5MGCN	04055977196351

Documentation

ERK Inhibitor - CAS 1049738-54-6 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

ERK Inhibitor - CAS 1049738-54-6 - Calbiochem 分析证书

标题	批号
328006	输入批号

参考

参考信息概述
Hancock, C. N., et al. 2005. J. Med. Chem. 48, 4586.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	08-April-2011 RFH
Synonyms	3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione, HCl
Description	A cell-permeable and reversible thiazolidinedione compound that displays anti-proliferative properties (IC₅₀ ≤25 µM in HeLa, A549, and SUM-159 tumor cells). Preferentially binds to ERK2 with a K_D of ~5 µM and prevents its interaction with protein substrates. Shown to block ERK-mediated phosphorylation of ribosomal S6 kinase-1 (RSK-1) and ternary complex factor Elk-1 in HeLa cells, while exhibiting little effect on ERK1/2 phosphorylation by MEK1/2.
Form	Light yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	1049738-54-6
Chemical formula	C₁₄H₁₆N₂O₃S • HCl
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (10 mg/ml)
Storage	Protect from light +2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Hancock, C. N., et al. 2005. J. Med. Chem. 48, 4586.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > MAP Kinase Inhibitors

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