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328000 Sigma-AldrichERK Activation Inhibitor Peptide I, Cell-Permeable - Calbiochem

The ERK Activation Inhibitor Peptide I, Cell-Permeable controls the biological activity of ERK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: Ste-MEK1₁₃, Ste-MPKKKPTPIQLNP-NH₂, Erk Inhibitor IV

Primary Target: MEK

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概述

Replacement Information

重要规格表

Empirical Formula
C₈₆H₁₅₃N₁₉O₁₇S

价格及供货情况

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Description
Overview	A cell-permeable and reversible stearated 13-amino acid peptide corresponding to the N-terminus of MEK1 (MAPKK) that acts as a specific inhibitor of ERK activation and blocks the transcriptional activity of Elk1. Selectively binds to ERK2 and prevents its interaction with MEK (IC₅₀ = 2.5 µM). Potently blocks ERK activation in PMA-stimulated NIH 3T3 cells and NGF-treated PC12 cells (IC₅₀ = 13 µM). Does not affect the activation of JNKs or p38.
Catalogue Number	328000
Brand Family	Calbiochem®
Synonyms	Ste-MEK1₁₃, Ste-MPKKKPTPIQLNP-NH₂, Erk Inhibitor IV

References
References	Kelemen, B.R., et al. 2002. J. Biol. Chem. 277, 8741.

Product Information
ATP Competitive	N
Form	White lyophilized solid
Formulation	Supplied as a trifluoroacetate salt.
Hill Formula	C₈₆H₁₅₃N₁₉O₁₇S
Chemical formula	C₈₆H₁₅₃N₁₉O₁₇S
Hygroscopic	Hygroscopic
Reversible	Y
Quality Level	MQ100

Applications

Biological Information
Primary Target	MEK
Primary Target IC<sub>50</sub>	2.5 µM
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y
Peptide Sequence	Ste-Met-Pro-Lys-Lys-Lys-Pro-Thr-Pro-Ile-Gln-Leu-Asn-Pro-NH₂ (Ste = stearated)

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Blue Ice Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
328000-1MGCN	04055977196337

Documentation

ERK Activation Inhibitor Peptide I, Cell-Permeable - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

ERK Activation Inhibitor Peptide I, Cell-Permeable - Calbiochem 分析证书

标题	批号
328000	输入批号

参考

参考信息概述
Kelemen, B.R., et al. 2002. J. Biol. Chem. 277, 8741.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	04-January-2010 RFH
Synonyms	Ste-MEK1₁₃, Ste-MPKKKPTPIQLNP-NH₂, Erk Inhibitor IV
Description	A cell-permeable, reversible, and stearated, 13-amino acid peptide corresponding to the N-terminus of MAPK/ERK kinase (MEK). Acts as a specific inhibitor of ERK activation and blocks the transcriptional activity of ELK1. Selectively binds to ERK2 and prevents its interaction with MEK (IC₅₀ = 2.5 µM). Shown to block ERK activity in PMA-stimulated NIH3T3 cells and NGF-treated PC12 cells (IC₅₀ = 13 µM). Does not affect the activation of either JNKs or p38 MAP kinase.
Form	White lyophilized solid
Formulation	Supplied as a trifluoroacetate salt.
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₈₆H₁₅₃N₁₉O₁₇S
Peptide Sequence	Ste-Met-Pro-Lys-Lys-Lys-Pro-Thr-Pro-Ile-Gln-Leu-Asn-Pro-NH₂ (Ste = stearated)
Purity	≥95% by HPLC
Solubility	DMSO (5 mg/ml) or H₂O (1 mg/ml)
Storage	Protect from light -20°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Kelemen, B.R., et al. 2002. J. Biol. Chem. 277, 8741.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > MAP Kinase Inhibitors

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