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324879 Sigma-AldrichEIF2AK3 Activator, CCT020312 - CAS 324759-76-4 - Calbiochem

The EIF2AK3 Activator, CCT020312 modulates the biological activity of EIF2AK3.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 6-Bromo-3-[5-(4-bromo-phenyl)-1-(3-diethylamino-propionyl)-4,5-dihydro-1H-pyrazol-3-yl]-4-phenyl-1H-quinolin-2-one, PERK activator, CCT020312

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
324759-76-4	C₃₁H₃₀Br₂N₄O₂

价格及供货情况

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Description
Overview	A dihydropyrazol derivative that acts as a selective activator of eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3/PERK) and increases the phosphorylation of EIF2A at Ser51 in HT29 and MCF7 cells. Does not inhibit the activity of cyclin dependent kinases, but causes a rapid loss of cyclin D expression. Also shown to block Rb protein phosphorylation (EC₅₀ = 4.2 µM) in HT29 cells. Reported to sensitize cancer cells with defective taxane-induced EIF2A phosphorylation to paclitaxel treatment. Induces a long-term inhibition of cell proliferation even after its removal (GI₅₀ = 3.1 µM).
Catalogue Number	324879
Brand Family	Calbiochem®
Synonyms	6-Bromo-3-[5-(4-bromo-phenyl)-1-(3-diethylamino-propionyl)-4,5-dihydro-1H-pyrazol-3-yl]-4-phenyl-1H-quinolin-2-one, PERK activator, CCT020312

References
References	Stockwell, S. R., et al. 2011. Plos One In press.

Product Information
CAS number	324759-76-4
Form	Yellowish-white solid
Hill Formula	C₃₁H₃₀Br₂N₄O₂
Chemical formula	C₃₁H₃₀Br₂N₄O₂
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥98% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
324879-5MGCN	04055977196085

Documentation

EIF2AK3 Activator, CCT020312 - CAS 324759-76-4 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

EIF2AK3 Activator, CCT020312 - CAS 324759-76-4 - Calbiochem 分析证书

标题	批号
324879	输入批号

参考

参考信息概述
Stockwell, S. R., et al. 2011. Plos One In press.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	24-August-2012 JSW
Synonyms	6-Bromo-3-[5-(4-bromo-phenyl)-1-(3-diethylamino-propionyl)-4,5-dihydro-1H-pyrazol-3-yl]-4-phenyl-1H-quinolin-2-one, PERK activator, CCT020312
Description	A dihydropyrazol derivative that acts as a selective activator of eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3/PERK) and increases the phosphorylation of EIF2A at Ser51 in HT29 and MCF7 cells. Does not inhibit the activity of cyclin dependent kinases, but causes a rapid loss of cyclin D expression. Also shown to block Rb protein phosphorylation (EC₅₀ = 4.2 µM) in HT29 cells. Reported to sensitize cancer cells with defective taxane-induced EIF2A phosphorylation to paclitaxel treatment. Induces a long-term inhibition of cell proliferation even after its removal (GI₅₀ = 3.1 µM).
Form	Yellowish-white solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	324759-76-4
Chemical formula	C₃₁H₃₀Br₂N₄O₂
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (50 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Stockwell, S. R., et al. 2011. Plos One In press.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest

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