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322338 Sigma-AldrichDvl-PDZ Domain Inhibitor II - CAS 294891-81-9 - Calbiochem

The Dvl-PDZ Domain Inhibitor II, also referenced under CAS 294891-81-9, controls the biological activity of Dvl-PDZ. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 2-((3-(2-Phenylacetyl)amino)benzoyl)amino)benzoic acid, 3289-8625, Wnt Pathway Inhibitor IV

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
294891-81-9	C₂₂H₁₈N₂O₄

价格及供货情况

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Description
Overview	A cell-permeable amidobenzanilide compound that disrupts Fz-Dvl (frizzled-dishevelled) interaction by targeting the PDZ domain (K_d = 10.6 µM) of Dvl, blocking Wnt3a-induced (10 ng/ml) transcription activity (~50% inhibition at 3 µM in 293 cell SuperTopflash reporter assays) and suppressing the Wnt pathway-dependent growth of prostate cancer PC-3 cells (by 16% in 72 h at ≥50 µM; IC₅₀ = 12.5 µM). Shown to effectively prevent Wnt3A mRNA injection-induced xenopus embryo deformation (effective conc. = 25 µM) and suppress Wnt pathway-mediated apoptosis of the hyaloid vescular endothelial cells in the mouse eyes via vitreous injection (144 fmol/120 nl/eye) in vivo.
Catalogue Number	322338
Brand Family	Calbiochem®
Synonyms	2-((3-(2-Phenylacetyl)amino)benzoyl)amino)benzoic acid, 3289-8625, Wnt Pathway Inhibitor IV

References
References	Grandy, D., et al. 2009. J. Biol. Chem. 284, 16256.

Product Information
CAS number	294891-81-9
Form	White solid
Hill Formula	C₂₂H₁₈N₂O₄
Chemical formula	C₂₂H₁₈N₂O₄
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥95% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
322338-10MGCN	04055977216356

Documentation

Dvl-PDZ Domain Inhibitor II - CAS 294891-81-9 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Dvl-PDZ Domain Inhibitor II - CAS 294891-81-9 - Calbiochem 分析证书

标题	批号
322338	输入批号

参考

参考信息概述
Grandy, D., et al. 2009. J. Biol. Chem. 284, 16256.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	07-April-2011 RFH
Synonyms	2-((3-(2-Phenylacetyl)amino)benzoyl)amino)benzoic acid, 3289-8625, Wnt Pathway Inhibitor IV
Description	A cell-permeable amidobenzanilide compound that disrupts Fz-Dvl (frizzled-dishevelled) interaction by targeting the PDZ domain (K_d = 10.6 µM) of Dvl, blocking Wnt3a-induced (10 ng/ml) transcription activity (~50% inhibition at 3 µM in 293 cell SuperTopflash reporter assays) and suppressing the Wnt pathway-dependent growth of prostate cancer PC-3 cells (by 16% in 72 h at ≥50 µM; IC₅₀ = 12.5 µM). Shown to effectively prevent Wnt3A mRNA injection-induced xenopus embryo deformation (effective conc. = 25 µM) and suppress Wnt pathway-mediated apoptosis of the hyaloid vescular endothelial cells in the mouse eyes via vitreous injection (144 fmol/120 nl/eye) in vivo.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	294891-81-9
Chemical formula	C₂₂H₁₈N₂O₄
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (50 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Grandy, D., et al. 2009. J. Biol. Chem. 284, 16256.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Stem Cell Biology > Wnt Signaling Inhibitors

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