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533982 Sigma-AldrichDock5 Inhibitor, C21 - CAS 54129-15-6 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
参考
Data Sheet

同义词: N-(3,5-Dichlorophenyl)benzenesulfonamide

Primary Target: Dock5

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
54129-15-6	C₁₂H₉Cl₂NO₂S

价格及供货情况

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Description
Overview	A cell-permeable, bioavailable, non-toxic benzenesulfonamide compound that directly blocks Dock5-mediated Rac activation (k_cat/K_M = 7.9 x 10⁴ & 9.5 x 10⁴ M^-1s^-1 for Rac1 & Rac2 by Dock5-DHR2, respectively) with selectivity over RhoA and Cdc42. At higher concentrations, affects Dock1 and Dock2 guanine nucleotide exchange factor activity. Shown to reversibly perturb podosome organization and inhibit osteoclastic bone degradation in a dose-dependent manner. Efficiently prevents both arthritis and metastasis-induced bone loss while preserving bone formation in several osteolytic disease mouse model (25 mg/kg, i.p. or i.v., 5 days a week for 4 weeks). Unlike alendronate (Cat. No. 126855), C21 does not impair bone formation. Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Catalogue Number	533982
Brand Family	Calbiochem®
Synonyms	N-(3,5-Dichlorophenyl)benzenesulfonamide

References
References	Vives, V., et al. 2015. Nat. Commun. 6, 6218. Vives, V., et al. 2011. J. Bone Miner. Res. 26, 1099.

Product Information
CAS number	54129-15-6
Form	Grey powder
Hill Formula	C₁₂H₉Cl₂NO₂S
Chemical formula	C₁₂H₉Cl₂NO₂S
Reversible	Y
Quality Level	MQ100

Applications

Biological Information
Primary Target	Dock5
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
5.33982.0001	04055977281729

Documentation

Dock5 Inhibitor, C21 - CAS 54129-15-6 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

参考

参考信息概述
Vives, V., et al. 2015. Nat. Commun. 6, 6218. Vives, V., et al. 2011. J. Bone Miner. Res. 26, 1099.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	14-July-2017 JSW
Synonyms	N-(3,5-Dichlorophenyl)benzenesulfonamide
Description	A cell-permeable, bioavailable, non-toxic benzenesulfonamide compound that directly blocks Dock5-mediated Rac activation (k_cat/K_M = 7.9 x 10⁴ & 9.5 x 10⁴ M^-1s^-1 for Rac1 & Rac2 by Dock5-DHR2, respectively) with selectivity over RhoA and Cdc42. At higher concentrations, affects Dock1 and Dock2 guanine nucleotide exchange factor activity. Shown to reversibly perturb podosome organization and inhibit osteoclastic bone degradation in a dose-dependent manner. Efficiently prevents both arthritis and metastasis-induced bone loss while preserving bone formation in several osteolytic disease mouse model (25 mg/kg, i.p. or i.v., 5 days a week for 4 weeks). Unlike alendronate (Cat. No. 126855), C21 does not impair bone formation.
Form	Grey powder
Intert gas (Yes/No)	Packaged under inert gas
CAS number	54129-15-6
Chemical formula	C₁₂H₉Cl₂NO₂S
Purity	≥98% by HPLC
Solubility	DMSO (50 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Vives, V., et al. 2015. Nat. Commun. 6, 6218. Vives, V., et al. 2011. J. Bone Miner. Res. 26, 1099.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > ATPase/GTPase Inhibitors > GTPase Inhibitors

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