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			96-Well Plate

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317700 Sigma-AldrichDkk-1 Inhibitor, WAY-262611, HCl - Calbiochem

Dkk-1 Inhibitor, WAY-262611, HCl, CAS 1123231-07-1, counteracts the antagonizing effect of Dkk-1 against Wnt-3a/LRP5 interaction. Prevents Dkk-1-mediated Kr2/LRP5/Dkk-1 complex formation.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: (1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine, Wnt Pathway Activator VI

Recommended Products

概述

Replacement Information

重要规格表

Empirical Formula
C₂₀H₂₂N₄ • HCl

价格及供货情况

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Description
Overview	A 2-aminopyrimidine compound that counteracts the antagonizing effect of Dkk-1 (Dickkopf-1) against Wnt-3a/LRP5 interaction and prevents Dkk-1-mediated Kr2/LRP5/Dkk-1 complex formation and internalization. Shown to successfully rescue cellular response to Wnt-3a stimulation in the presence of Dkk-1 (EC₅₀ = 0.63 µM in a cell-based TCF-luciferase assay) in vitro and double the tibia trabecular bone formation in OVX rats in a period of 28 days via an oral dose of 10 mg/kg/day in vivo.
Catalogue Number	317700
Brand Family	Calbiochem®
Synonyms	(1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine, Wnt Pathway Activator VI

References
References	Pelletier, J.C., et al. 2009. J. Med. Chem. 52, 6962.

Product Information
Form	Yellow powder
Formulation	Supplied as a hydrochloride salt.
Hill Formula	C₂₀H₂₂N₄ • HCl
Chemical formula	C₂₀H₂₂N₄ • HCl
Structure formula Image
Quality Level	MQ100

Applications
Application	Dkk-1 Inhibitor, WAY-262611, HCl, CAS 1123231-07-1, counteracts the antagonizing effect of Dkk-1 against Wnt-3a/LRP5 interaction. Prevents Dkk-1-mediated Kr2/LRP5/Dkk-1 complex formation.

Biological Information
Purity	≥95% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
317700-10MGCN	04055977216288

Documentation

Dkk-1 Inhibitor, WAY-262611, HCl - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Dkk-1 Inhibitor, WAY-262611, HCl - Calbiochem 分析证书

标题	批号
317700	输入批号

参考

参考信息概述
Pelletier, J.C., et al. 2009. J. Med. Chem. 52, 6962.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	30-August-2016 JSW
Synonyms	(1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine, Wnt Pathway Activator VI
Description	A 2-aminopyrimidine compound that counteracts the antagonizing effect of Dkk-1 (Dickkopf-1) against Wnt-3a/LRP5 interaction and prevents Dkk-1-mediated Kr2/LRP5/Dkk-1 complex formation and internalization. Shown to successfully rescue cellular response to Wnt-3a stimulation in the presence of Dkk-1 (EC₅₀ = 0.63 µM in a cell-based TCF-luciferase assay) in vitro and double the tibia trabecular bone formation in OVX rats in a period of 28 days via an oral dose of 10 mg/kg/day in vivo.
Form	Yellow powder
Formulation	Supplied as a hydrochloride salt.
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₂₀H₂₂N₄ • HCl
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (25 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Pelletier, J.C., et al. 2009. J. Med. Chem. 52, 6962.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest

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