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265005 Sigma-AldrichDexamethasone - CAS 50-02-2 - Calbiochem

Dexamethasone, CAS 50-02-2, is one of the most active and highly stable glucocorticoids. Inhibits the expression of inducible, but not constitutive NOS in vascular endothelial cells (IC50 = 5 nM).

Dexamethasone - CAS 50-02-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet

同义词: 9α-Fluoro-16α-methylprednisolone

Primary Target: Phosphorylation of rb protein

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
50-02-2	C₂₂H₂₉FO₅

价格及供货情况

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Description
Overview	Most active and highly stable glucocorticoid. Causes a reduction in cyclin A and Cdk2 activity, and inhibition of G₁/S transition in osteoblasts. Inhibits the phosphorylation of retinoblastoma (Rb) protein. Inhibits the expression of inducible but not constitutive nitric oxide synthase in vascular endothelial cells (IC₅₀ = 5 nM). Enhances active cation transport in aortic smooth muscle cells by stimulating the Na⁺ - K⁺ pump. Induces apoptosis in human thymocytes.
Catalogue Number	265005
Brand Family	Calbiochem®
Synonyms	9α-Fluoro-16α-methylprednisolone

References
References	Reil, T.D., et al. 2000. J. Surg. Res. 92, 108. Smith, E., et al. 2000. J. Biol. Chem. 275, 1992. Petit, P.X., et al. 1995. J. Cell Biol. 130, 157. Stern, N., et al. 1994. Am. J. Hypertens. 7, 146. Donis, J.A., et al. 1993. Biotechniques 15, 786. Ohoka, Y., et al. 1993. Biochem. Biophys. Res. Commun. 197, 916. Sarin, A., et al. 1993. J. Exp. Med. 178, 1693. Vandewalle, A., et al. 1993. J. Cell Physiol. 156, 383. Nieto, M.A., et al. 1992. Clin. Exp. Immunol. 88, 341. Walsh, D., and Avashia, J. 1992. Cleveland Clin. J. Med. 59, 505. Warters, R.L. 1992. Cancer Res. 52, 883. Sperber, K., et al. 1991. J. Allergy Clin. Immunol. 87, 490. Radomski, M.W., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 10043. Bettger, W.J., et al. 1981. Proc. Natl. Acad. Sci. USA 78, 5588.

References

Reil, T.D., et al. 2000. J. Surg. Res. 92, 108.
Smith, E., et al. 2000. J. Biol. Chem. 275, 1992.
Petit, P.X., et al. 1995. J. Cell Biol. 130, 157.
Stern, N., et al. 1994. Am. J. Hypertens. 7, 146.
Donis, J.A., et al. 1993. Biotechniques 15, 786.
Ohoka, Y., et al. 1993. Biochem. Biophys. Res. Commun. 197, 916.
Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
Vandewalle, A., et al. 1993. J. Cell Physiol. 156, 383.
Nieto, M.A., et al. 1992. Clin. Exp. Immunol. 88, 341.
Walsh, D., and Avashia, J. 1992. Cleveland Clin. J. Med. 59, 505.
Warters, R.L. 1992. Cancer Res. 52, 883.
Sperber, K., et al. 1991. J. Allergy Clin. Immunol. 87, 490.
Radomski, M.W., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 10043.
Bettger, W.J., et al. 1981. Proc. Natl. Acad. Sci. USA 78, 5588.

Product Information
CAS number	50-02-2
ATP Competitive	N
Form	White solid
Hill Formula	C₂₂H₂₉FO₅
Chemical formula	C₂₂H₂₉FO₅
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications
Application	Dexamethasone, CAS 50-02-2, is one of the most active and highly stable glucocorticoids. Inhibits the expression of inducible, but not constitutive NOS in vascular endothelial cells (IC50 = 5 nM).

Biological Information
Primary Target	Phosphorylation of rb protein
Primary Target IC<sub>50</sub>	5 nM Inhibiting the expression of inducible but not constitutive nitric oxide synthase in vascular endothelial cells
Purity	≥99% by TLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	TU3980000

Safety Information
R Phrase	R: 36/37/38-43-63 Irritating to eyes, respiratory system and skin. May cause sensitization by skin contact. Possible risk of harm to the unborn child.
S Phrase	S: 24-26-36/37 Avoid contact with skin. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Carcinogenic / Teratogenic
Storage	+2°C to +8°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
265005-100MGCN	04055977198508

Documentation

Dexamethasone - CAS 50-02-2 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Dexamethasone - CAS 50-02-2 - Calbiochem 分析证书

标题	批号
265005	输入批号

参考

参考信息概述
Reil, T.D., et al. 2000. J. Surg. Res. 92, 108. Smith, E., et al. 2000. J. Biol. Chem. 275, 1992. Petit, P.X., et al. 1995. J. Cell Biol. 130, 157. Stern, N., et al. 1994. Am. J. Hypertens. 7, 146. Donis, J.A., et al. 1993. Biotechniques 15, 786. Ohoka, Y., et al. 1993. Biochem. Biophys. Res. Commun. 197, 916. Sarin, A., et al. 1993. J. Exp. Med. 178, 1693. Vandewalle, A., et al. 1993. J. Cell Physiol. 156, 383. Nieto, M.A., et al. 1992. Clin. Exp. Immunol. 88, 341. Walsh, D., and Avashia, J. 1992. Cleveland Clin. J. Med. 59, 505. Warters, R.L. 1992. Cancer Res. 52, 883. Sperber, K., et al. 1991. J. Allergy Clin. Immunol. 87, 490. Radomski, M.W., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 10043. Bettger, W.J., et al. 1981. Proc. Natl. Acad. Sci. USA 78, 5588.

参考信息概述

小册子

标题
Tools and Tips for Analyzing Apoptosis

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	21-November-2008 RFH
Synonyms	9α-Fluoro-16α-methylprednisolone
Description	Most active and highly stable glucocorticoid. Inhibits the expression of inducible but not constitutive nitric oxide synthase in vascular endothelial cells (IC₅₀ = 5 nM). Enhances active cation transport in aortic smooth muscle cells by stimulating the Na⁺-K⁺ pump. Has anti-inflammatory and antirheumatic properties. Induces apoptosis in human thymocytes. In general, 500-1000 nM of dexamethasone is sufficient to induce apoptosis following a 6 h incubation at 37°C.
Form	White solid
CAS number	50-02-2
RTECS	TU3980000
Chemical formula	C₂₂H₂₉FO₅
Structure formula
Purity	≥99% by TLC
Solubility	DMSO (25 mg/ml), chloroform or Ethanol
Storage	+2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Toxicity	Carcinogenic / Teratogenic
Merck USA index	14, 2943
References	Reil, T.D., et al. 2000. J. Surg. Res. 92, 108. Smith, E., et al. 2000. J. Biol. Chem. 275, 1992. Petit, P.X., et al. 1995. J. Cell Biol. 130, 157. Stern, N., et al. 1994. Am. J. Hypertens. 7, 146. Donis, J.A., et al. 1993. Biotechniques 15, 786. Ohoka, Y., et al. 1993. Biochem. Biophys. Res. Commun. 197, 916. Sarin, A., et al. 1993. J. Exp. Med. 178, 1693. Vandewalle, A., et al. 1993. J. Cell Physiol. 156, 383. Nieto, M.A., et al. 1992. Clin. Exp. Immunol. 88, 341. Walsh, D., and Avashia, J. 1992. Cleveland Clin. J. Med. 59, 505. Warters, R.L. 1992. Cancer Res. 52, 883. Sperber, K., et al. 1991. J. Allergy Clin. Immunol. 87, 490. Radomski, M.W., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 10043. Bettger, W.J., et al. 1981. Proc. Natl. Acad. Sci. USA 78, 5588.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Nitric Oxide and Oxidative Stress > Nitric Oxide Synthase (NOS) Inhibitors

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