数量	产品目录编号	订购说明	数量 / 包装	公开价
			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

259545 Sigma-AldrichDeoxyhypusine Synthase Inhibitor, GC7 - CAS 150333-69-0 - Calbiochem

The Deoxyhypusine Synthase Inhibitor, GC7, also referenced under CAS 150333-69-0, controls the biological activity of Deoxyhypusine Synthase.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: N1-guanyl-1,7-diamine-heptane, 1-(7-ammonioheptyl)guanidinium sulfate

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
150333-69-0	C₈H₂₂N₄O₄S

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
259545-10MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	玻璃瓶	10 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	A cell-permeable inhibitor that targets the spermidine-binding site of Deoxyhypusine Synthase (K_i = 9.7 nM), an enzyme which is responsible for the first step hypunisation of eukaryotic initiation factor 5A (eIF5A). In vivo, it demonstrates almost complete cessation of hypusine formation in CHO cells at ≥ 1 µM. Several studies indicate this compound as a useful tool for the down-regulation of eIF5A, a protein essential for cell proliferation. For example, it exhibits an anti-proliferative effect on both BCR-ABL -positive and -negative leukemia cell lines (K562 and HL-60) dose-dependently, at concentrations between 5 µM and 40 µM. In addition, it is shown to significantly impair the growth and invasion of primary HCC cells (HepG2 and Hep3B) in the 10-20 µM range, and against non-tumorigenic CL-48 cells at concentrations as high as 40 µM, with no apparent cytotoxicity. At 25 µM, GC7 treatment is shown to reverse eIF5a-mediated Skeletal Muscle Stem Cell Differentiation.
Catalogue Number	259545
Brand Family	Calbiochem®
Synonyms	N1-guanyl-1,7-diamine-heptane, 1-(7-ammonioheptyl)guanidinium sulfate

References
References	Lee, N.P., et al. 2010. Int J Cancer. 4, 968. Luchessi, A., et al. 2008. J Cell Physiol. 3, 480. Balabanov, S., et al. 2007. Blood. 4, 1701. Jakus, J., et al. 1993. J Biol Chem. 18, 13151.

Product Information
CAS number	150333-69-0
Form	White powder
Hill Formula	C₈H₂₂N₄O₄S
Chemical formula	C₈H₂₂N₄O₄S
Hygroscopic	Hygroscopic
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	>95% by NMR

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped with Blue Ice or with Dry Ice
Toxicity	Standard Handling
Storage	-20°C
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
259545-10MGCN	04055977217421

Documentation

Deoxyhypusine Synthase Inhibitor, GC7 - CAS 150333-69-0 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Deoxyhypusine Synthase Inhibitor, GC7 - CAS 150333-69-0 - Calbiochem 分析证书

标题	批号
259545	输入批号

参考

参考信息概述
Lee, N.P., et al. 2010. Int J Cancer. 4, 968. Luchessi, A., et al. 2008. J Cell Physiol. 3, 480. Balabanov, S., et al. 2007. Blood. 4, 1701. Jakus, J., et al. 1993. J Biol Chem. 18, 13151.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	14-May-2012 JSW
Synonyms	N1-guanyl-1,7-diamine-heptane, 1-(7-ammonioheptyl)guanidinium sulfate
Description	A cell-permeable inhibitor that targets the spermidine-binding site of Deoxyhypusine Synthase (K_i = 9.7 nM), an enzyme which is responsible for the first step hypunisation of eukaryotic initiation factor 5A (eIF5A). In vivo, it demonstrates almost complete cessation of hypusine formation in CHO cells at ≥ 1 µM. Several studies indicate this compound as a useful tool for the down-regulation of eIF5A, a protein essential for cell proliferation. For example, it exhibits an anti-proliferative effect on both BCR-ABL -positive and -negative leukemia cell lines (K562 and HL-60) dose-dependently, at concentrations between 5 µM and 40 µM. In addition, it is shown to significantly impair the growth and invasion of primary HCC cells (HepG2 and Hep3B) in the 10-20 µM range, and against non-tumorigenic CL-48 cells at concentrations as high as 40 µM, with no apparent cytotoxicity. At 25 µM, GC7 treatment is shown to reverse eIF5a-mediated Skeletal Muscle Stem Cell Differentiation.
Form	White powder
CAS number	150333-69-0
Chemical formula	C₈H₂₂N₄O₄S
Structure formula
Purity	>95% by NMR
Solubility	H₂O (25 mg/ml; clear, colorless solution)
Storage	-20°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Lee, N.P., et al. 2010. Int J Cancer. 4, 968. Luchessi, A., et al. 2008. J Cell Physiol. 3, 480. Balabanov, S., et al. 2007. Blood. 4, 1701. Jakus, J., et al. 1993. J Biol Chem. 18, 13151.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest

此产品已添加到您的购物车。