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Iron chelating agent. Completely protects against dopamine-induced cell death. Has also been shown to interfere with hydroxyl radical formation, which mediates tissue damage in several disease states. Shows anti-proliferative effect on vascular smooth muscle cells in vitro and in vivo. Can also inhibit the oxidative chemistry of peroxynitrite by reaction of the hydroxamic acid moieties with trans-peroxynitrous acid.
Catalogue Number
252750
Brand Family
Calbiochem®
Synonyms
Desferrioxamine Mesylate, DFOM, Iron Chelator II
References
References
Bergeron, R.J., et al. 1996. J. Med. Chem. 39, 1575. Ben-Shachar, D., et al. 1995. J. Neurochem. 64, 718. Denicola, A., et al. 1995. Free Radic. Biol. Med. 19, 11. Dzwigaj, S., and pererat, H., 1995. Free Radic. Res.14, 103. Dang, S., et al. 1994. Res. Commun. Mol. Pathol. Pharmacol. 86, 43. Porreca, E., et al. 1994. Arterioscler. Thromb. 14, 299.
Harmful if swallowed. Irritating to eyes, respiratory system and skin. Limited evidence of a carcinogenic effect. May cause sensitization by inhalation and skin contact.
S Phrase
S: 22-26-36
Do not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Harmful & Carcinogenic / Teratogenic
Storage
+2°C to +8°C
Hygroscopic
Hygroscopic
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号
GTIN
252750-1GMCN
04055977217339
Documentation
Deferoxamine Mesylate - CAS 138-14-7 - Calbiochem MSDS
Deferoxamine Mesylate - CAS 138-14-7 - Calbiochem 分析证书
标题
批号
252750
参考
参考信息概述
Bergeron, R.J., et al. 1996. J. Med. Chem. 39, 1575. Ben-Shachar, D., et al. 1995. J. Neurochem. 64, 718. Denicola, A., et al. 1995. Free Radic. Biol. Med. 19, 11. Dzwigaj, S., and pererat, H., 1995. Free Radic. Res.14, 103. Dang, S., et al. 1994. Res. Commun. Mol. Pathol. Pharmacol. 86, 43. Porreca, E., et al. 1994. Arterioscler. Thromb. 14, 299.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
01-February-2024 JSW
Synonyms
Desferrioxamine Mesylate, DFOM, Iron Chelator II
Description
Parenteral iron chelating agent. Commonly used in therapy as a chelator of ferric iron in disorders of iron overload. Completely protects against dopamine-induced cell death. Has also been shown to interfere with hydroxyl radical formation, which mediates tissue damage in several disease states. Shows antiproliferative effects on vascular smooth muscle cells in vitro and in vivo. Can also inhibit the oxidative chemistry of peroxynitrite by reaction of the hydroxamic moieties with trans-peroxynitrous acid.
Form
Faint yellow powder
CAS number
138-14-7
RTECS
UG5310000
Chemical formula
C₂₅H₄₈N₆O₈·CH₄O₃S
Structure formula
Purity
≥98% by HPLC
Solubility
H₂O (50 mg/ml)
Storage
+2°C to +8°C
Hygroscopic
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Harmful & Carcinogenic / Teratogenic
Merck USA index
14, 2860
References
Bergeron, R.J., et al. 1996. J. Med. Chem. 39, 1575. Ben-Shachar, D., et al. 1995. J. Neurochem. 64, 718. Denicola, A., et al. 1995. Free Radic. Biol. Med. 19, 11. Dzwigaj, S., and pererat, H., 1995. Free Radic. Res.14, 103. Dang, S., et al. 1994. Res. Commun. Mol. Pathol. Pharmacol. 86, 43. Porreca, E., et al. 1994. Arterioscler. Thromb. 14, 299.
