662142 Sigma-AldrichDUB Inhibitor VI, P22077 - CAS 1247819-59-5 - Calbiochem
The DUB Inhibitor VI, P22077 controls the biological activity of DUB. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
More>> The DUB Inhibitor VI, P22077 controls the biological activity of DUB. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
同义词: USP7 Inhibitor II, USP47 Inhibitor II, P022077, 1-(5-(2,4-Difluorophenylthio)-4-nitrothiophen-2-yl)ethanone
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概述
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重要规格表
| CAS # | Empirical Formula |
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| 1247819-59-5 | C₁₂H₇F₂NO₃S₂ |
价格及供货情况
| 产品目录编号 | 库存情况 | 包装 | 数量 / 包装 | 价格 | 数量 | |
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| 662142-25MGCN |
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玻璃瓶 | 25 mg |
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| Description | |
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| Overview | A cell-permeable thiophenylethanone that is shown to inhibit USP7 and USP47 deubiquitinase activity (IC50 = 8.01 & 8.74 µM, respectively), while exhibiting much reduced affinity toward ATXN3, BAP1, and USP1, and displaying no inhibitory activity toward other known PR-619 (Cat. No. 662141) targets (IC50 >50 µM). Both P22077 and PR-619 are shown to increase overall protein polyubiquitination in HEK293T cells in a dose- and time-dependent manner (20 to 150 µM; 0.5 to 20 h), however PR619 treatment results in upregulation of both K48- and K63-linked, while P22077 exposure results in mainly enrichment of K48-linked polyUb chains. |
| Catalogue Number | 662142 |
| Brand Family | Calbiochem® |
| Synonyms | USP7 Inhibitor II, USP47 Inhibitor II, P022077, 1-(5-(2,4-Difluorophenylthio)-4-nitrothiophen-2-yl)ethanone |
| References | |
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| References | Altun, M., et al. 2011. Chem. Biol. 18, 1401. Tian, X., et al. 2011. Assay Drug Dev. Technol. 9, 165. |
| Product Information | |
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| CAS number | 1247819-59-5 |
| Form | Off-white solid |
| Hill Formula | C₁₂H₇F₂NO₃S₂ |
| Chemical formula | C₁₂H₇F₂NO₃S₂ |
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| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥98% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| 产品目录编号 | GTIN |
| 662142-25MGCN | 04055977261257 |
Documentation
DUB Inhibitor VI, P22077 - CAS 1247819-59-5 - Calbiochem 分析证书
| 标题 | 批号 |
|---|---|
| 662142 |
参考
| 参考信息概述 |
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| Altun, M., et al. 2011. Chem. Biol. 18, 1401. Tian, X., et al. 2011. Assay Drug Dev. Technol. 9, 165. |