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14-692 DAPK1 Protein, active, 10 µg

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14-692
10 µg  
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      概述

      Replacement Information
      Description
      Catalogue Number14-692
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionDAPK1 Protein, active, 10 µg
      OverviewN-terminal GST-tagged, recombinant, human DAPK1, amino acids 1-296
      References
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationActive, N-terminal GST-tagged, recombinant, human DAPK1, amino acids 1-296, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Sourceexpressed by baculovirus in Sf21 cells
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme
      Entrez Gene Number
      Entrez Gene SummaryDeath-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate.
      Gene Symbol
      • DAPK1
      • DAPK
      • DKFZp781I035
      Protein TargetDAPK1
      Purification MethodGlutathione agarose affinity chromatography
      Target Sub-FamilyCAMK
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P53355 # Calcium/calmodulin-dependent serine/threonine kinase which acts as a positive regulator of apoptosis.
      COFACTOR: Magnesium.
      SIZE: 1432 amino acids; 160286 Da
      SUBCELLULAR LOCATION: Cytoplasm. Note=Colocalizes with the actin filament system.
      SIMILARITY: SwissProt: P53355 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily. & Contains 10 ANK repeats. & Contains 1 death domain. & Contains 1 protein kinase domain.
      Molecular Weight60.9kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by phosphorylation of ZIPtide (Catalog #12-545)
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditionsstable 6 months at -70°C from date of shipment
      Packaging Information
      Material Size10 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      产品目录编号 GTIN
      14-692 04053252403835

      Documentation

      DAPK1 Protein, active, 10 µg MSDS

      职位

      物料安全数据表 (MSDS) 

      DAPK1 Protein, active, 10 µg 分析证书

      标题批号
      DAPK1, active - 33232U-D 33232U-D

      参考

      参考概述公共医疗ID
      DAP-kinase as a target for drug design in cancer and diseases associated with accelerated cell death.
      Bialik, Shani and Kimchi, Adi
      Semin. Cancer Biol., 14: 283-94 (2004)  2004

      15219621 15219621
      Epigenetic change in pituitary tumorigenesis.
      Farrell, W E and Clayton, R N
      Endocr. Relat. Cancer, 10: 323-30 (2003)  2003

      显示摘要
      12790793 12790793
      Structure, activity, regulation, and inhibitor discovery for a protein kinase associated with apoptosis and neuronal death.
      Velentza, Anastasia V, et al.
      Pharmacol. Ther., 93: 217-24 (2002)  2002

      显示摘要
      12191613 12191613
      The DAP-kinase family of proteins: study of a novel group of calcium-regulated death-promoting kinases.
      Shohat, Galit, et al.
      Biochim. Biophys. Acta, 1600: 45-50 (2002)  2002

      显示摘要
      12445458 12445458

      相关产品和应用

      Alternative Packsize

      产品目录编号 描述  
      14-692M DAPK1 Protein, active, 250 µg 显示价格及库存情况

      产品族

      种类

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases