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310500 Sigma-AldrichD-erythro-Sphingosine, N,N-Dimethyl- - CAS 119567-63-4 - Calbiochem

A cell-permeable and reversible inhibitor of protein kinase C (PKC; IC₅₀ = 12 µM) and stimulates Src kinase activity.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet

同义词: DMS, SK Inhibitor III, Sphingosine Kinase Inhibitor III

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
119567-63-4	C₂₀H₄₁NO₂

价格及供货情况

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Description
Overview	A cell-permeable and reversible inhibitor of protein kinase C (PKC; IC₅₀ = 12 µM) and stimulates Src kinase activity. Useful for inhibiting cell surface expression of selectins that promote adhesion of leukocytes or tumor cells to platelets and endothelial cells. Induces apoptosis in human leukemia HL-60 cells. An inhibitor of sphingosine kinase.
Catalogue Number	310500
Brand Family	Calbiochem®
Synonyms	DMS, SK Inhibitor III, Sphingosine Kinase Inhibitor III

References
References	Cuvillier, O., et al. 1996. Nature 381, 800. Ohta, H., et al. 1995. Cancer Res. 55, 691. Kimura, S., et al. 1992. Biochem. Pharmacol. 44, 1585. Hanada, K., et al. 1991. Biochemistry 30, 11682. Igarashi, Y., et al. 1990. J. Biol. Chem. 265, 5385.

Product Information
CAS number	119567-63-4
ATP Competitive	N
Form	Waxy solid/Clear oil
Hill Formula	C₂₀H₄₁NO₂
Chemical formula	C₂₀H₄₁NO₂
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	PKC
Primary Target IC<sub>50</sub>	12 µM against PKC
Purity	≥98% by TLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/37/38 Irritating to eyes, respiratory system and skin.
S Phrase	S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Irritant
Storage	-20°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
310500-5MGCN	04055977216837

Documentation

D-erythro-Sphingosine, N,N-Dimethyl- - CAS 119567-63-4 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

D-erythro-Sphingosine, N,N-Dimethyl- - CAS 119567-63-4 - Calbiochem 分析证书

标题	批号
310500	输入批号

参考

参考信息概述
Cuvillier, O., et al. 1996. Nature 381, 800. Ohta, H., et al. 1995. Cancer Res. 55, 691. Kimura, S., et al. 1992. Biochem. Pharmacol. 44, 1585. Hanada, K., et al. 1991. Biochemistry 30, 11682. Igarashi, Y., et al. 1990. J. Biol. Chem. 265, 5385.

小册子

标题
Bioactive Lipids Technical Bulletin
Caspases and other Apoptosis Related Tools Brochure

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	11-January-2010 RFH
Synonyms	DMS, SK Inhibitor III, Sphingosine Kinase Inhibitor III
Description	A cell-permeable and reversible inhibitor of protein kinase C (IC₅₀ = 12 µM) and enhances src kinase activity. Useful for inhibiting cell surface expression of selectins that promote adhesion of leukocytes or tumor cells to platelets and endothelial cells. Induces apoptosis in human leukemia HL-60 cells.
Form	Waxy solid/Clear oil
CAS number	119567-63-4
Chemical formula	C₂₀H₄₁NO₂
Structure formula
Purity	≥98% by TLC
Solubility	DMSO (5 mg/ml), Ethanol, or Methanol
Storage	-20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
Toxicity	Irritant
References	Cuvillier, O., et al. 1996. Nature 381, 800. Ohta, H., et al. 1995. Cancer Res. 55, 691. Kimura, S., et al. 1992. Biochem. Pharmacol. 44, 1585. Hanada, K., et al. 1991. Biochemistry 30, 11682. Igarashi, Y., et al. 1990. J. Biol. Chem. 265, 5385.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Lipid Signaling Inhibitors > Sphingosine Kinase Inhibitors

Life Science Research > Inhibitors and Biochemicals > Biochemicals > Lipids > Sphingolipids

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