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Biologically active, cell-permeable, non-physiological ceramide analog. Inhibits cell growth and induces apoptosis in HL-60 cells. Induces intranucleosomal DNA fragmentation. An activator of heterotrimeric protein phosphatase 2A (PP2A). Stimulates a cytosolic serine/threonine protein phosphatase in T9 cells at concentrations as low as 100 nM. Activates stress activated protein kinase (SAPK) in HL-60 human promyelocytic cells.
Catalogue Number
110145
Brand Family
Calbiochem®
Synonyms
C₂ Ceramide
References
References
Westwick, J.K., et al. 1995. J. Biol. Chem.270, 22689. Cifone, M.G., et al. 1994. J. Exp. Med.180, 1547. Hannun, Y.A. 1994. J. Biol. Chem. 269, 3125. Bielawska, A., et al. 1993. J. Biol. Chem.268, 26226. Obeid, L.M., et al. 1993. Science259, 1769. Ballou, L.R., et al. 1992. J. Biol. Chem.267, 20044. Dobrowsky, R.T., and Hannun, Y.A. 1992. J. Biol. Chem.267, 5048.
Inhibits cell growth and induces apoptosis in HL-60 cells
Purity
≥98% by TLC
Physicochemical Information
Cell permeable
Y
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R Phrase
R: 36/37/38
Irritating to eyes, respiratory system and skin.
S Phrase
S: 26-36
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Irritant
Storage
-20°C
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 month at -20°C. Alcohol stock solutions are stable for <1 week at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号
GTIN
110145-5MGCN
07790788055585
Documentation
D-erythro-Sphingosine, N-Acetyl- - CAS 3102-57-6 - Calbiochem 分析证书
标题
批号
110145
参考
参考信息概述
Westwick, J.K., et al. 1995. J. Biol. Chem.270, 22689. Cifone, M.G., et al. 1994. J. Exp. Med.180, 1547. Hannun, Y.A. 1994. J. Biol. Chem. 269, 3125. Bielawska, A., et al. 1993. J. Biol. Chem.268, 26226. Obeid, L.M., et al. 1993. Science259, 1769. Ballou, L.R., et al. 1992. J. Biol. Chem.267, 20044. Dobrowsky, R.T., and Hannun, Y.A. 1992. J. Biol. Chem.267, 5048.
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
07-April-2008 RFH
Synonyms
C₂ Ceramide
Description
Biologically active, cell-permeable, non-physiological ceramide analog. Inhibits cell growth and induces apoptosis of HL-60 cells. Induces intranucleosomal DNA fragmentation. An activator of heterotrimeric protein phosphatase 2A. Stimulates a cytosolic serine/threonine protein phosphatase in T9 cells at concentrations as low as 100 nM. Activates stress-activated protein (SAP) kinase in HL-60 human promyelocytic cells.
Form
White to off-white solid
CAS number
3102-57-6
Chemical formula
C₂₀H₃₉NO₃
Structure formula
Purity
≥98% by TLC
Solubility
DMSO (25 mg/ml), Ethanol (5 mg/ml) or Methanol (5 mg/ml). When diluting into aqueous solution, sonication may be necessary to achieve a uniform suspension.
Storage
-20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 month at -20°C. Alcohol stock solutions are stable for <1 week at -20°C.
Toxicity
Irritant
References
Westwick, J.K., et al. 1995. J. Biol. Chem.270, 22689. Cifone, M.G., et al. 1994. J. Exp. Med.180, 1547. Hannun, Y.A. 1994. J. Biol. Chem. 269, 3125. Bielawska, A., et al. 1993. J. Biol. Chem.268, 26226. Obeid, L.M., et al. 1993. Science259, 1769. Ballou, L.R., et al. 1992. J. Biol. Chem.267, 20044. Dobrowsky, R.T., and Hannun, Y.A. 1992. J. Biol. Chem.267, 5048.
