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138001 Sigma-AldrichD-Amino Acid Oxidase Inhibitor II, CBIO - CAS 61977-29-5 - Calbiochem

The D-Amino Acid Oxidase Inhibitor II, CBIO, also referenced under CAS 61977-29-5, controls the biological activity of D-Amino Acid Oxidase.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 6-Chloro-1,2-benzisoxazol-3(2H)-one, 6-Chlorobenzo[d]isoxazol-3-ol, D-AAO Inhibitor II, CBIO

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
61977-29-5	C₇H₄ClNO₂

价格及供货情况

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Description
Overview	A cell-permeable benzisoxazolone compound that potently inhibits D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) activity (IC₅₀ = 90 and 150/188 nM against rat spinal cord and porcine kidney DAO, respectively) in a reversible and D-serine-competitive (K_i = 100 nM) manner. Upon co-administration, CBIO (30 mg/kg, p.o.) markedly prolongs the half-life of orally administered D-serine (30 mg/kg) in plasma, resulting in enhanced rat brain D-serine level (60% vs. 25% above basal, respectively, with vs. without CBIO). Direct intrathecal/spinal CBIO injection either before (ED₅₀ =60 ng) or after (ED₅₀ = 170 ng) subcutaneous formalin injection (50 µl 5% solution) greatly alleviates formalin-induced late phase tonic pain (E_max =67%), but not early phase acute nociception in rats in vivo.
Catalogue Number	138001
Brand Family	Calbiochem®
Synonyms	6-Chloro-1,2-benzisoxazol-3(2H)-one, 6-Chlorobenzo[d]isoxazol-3-ol, D-AAO Inhibitor II, CBIO

References
References	Gong, N., et al. 2011. J. Pharmacol. Exp. Ther. 336, 282. Ferraris, D., et al. 2008. J. Med. Chem. 51, 3357.

Product Information
CAS number	61977-29-5
Form	Off-white powder
Hill Formula	C₇H₄ClNO₂
Chemical formula	C₇H₄ClNO₂
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥97% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/37/38 Irritating to eyes, respiratory system and skin.

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity	Irritant
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
138001-50MGCN	04055977222319

Documentation

D-Amino Acid Oxidase Inhibitor II, CBIO - CAS 61977-29-5 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

D-Amino Acid Oxidase Inhibitor II, CBIO - CAS 61977-29-5 - Calbiochem 分析证书

标题	批号
138001	输入批号

参考

参考信息概述
Gong, N., et al. 2011. J. Pharmacol. Exp. Ther. 336, 282. Ferraris, D., et al. 2008. J. Med. Chem. 51, 3357.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	24-October-2011 RFH
Synonyms	6-Chloro-1,2-benzisoxazol-3(2H)-one, 6-Chlorobenzo[d]isoxazol-3-ol, D-AAO Inhibitor II, CBIO
Description	A cell-permeable benzisoxazolone compound that potently inhibits D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) activity (IC₅₀ = 90 and 150/188 nM against rat spinal cord and porcine kidney DAO, respectively) in a reversible and D-serine-competitive (K_i = 100 nM) manner. Upon co-administration, CBIO (30 mg/kg, p.o.) markedly prolongs the half-life of orally administered D-serine (30 mg/kg) in plasma, resulting in enhanced rat brain D-serine level (60% vs. 25% above basal, respectively, with vs. without CBIO). Direct intrathecal/spinal CBIO injection either before (ED₅₀ =60 ng) or after (ED₅₀ = 170 ng) subcutaneous formalin injection (50 µl 5% solution) greatly alleviates formalin-induced late phase tonic pain (E_max =67%), but not early phase acute nociception in rats in vivo.
Form	Off-white powder
Intert gas (Yes/No)	Packaged under inert gas
CAS number	61977-29-5
Chemical formula	C₇H₄ClNO₂
Structure formula
Purity	≥97% by HPLC
Solubility	DMSO (50 mg/ml). It is recommended to prepare a stock solution for 6 month use each time and store the unreconstituted material in solid form, protected from moisture and preferably under inert gas, for best long-term stability during storage.
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Irritant
References	Gong, N., et al. 2011. J. Pharmacol. Exp. Ther. 336, 282. Ferraris, D., et al. 2008. J. Med. Chem. 51, 3357.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest

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